Abstract
This study examined the relationship between longitudinal clinical course and sleep and cortisol findings in adolescent unipolar major depressive disorder (MDD). Subjects were 28 adolescents (15.4 ± 1.3 years) systematically diagnosed with unipolar MDD and 35 group-matched normal controls who participated in EEG sleep and neuroendocrine studies. Follow-up clinical assessments were conducted 7.0 ± 0.5 years later in 94% of the original cohort. Although initial group comparisons failed to show significant differences in biologic measures, analyses incorporating clinical follow-up reveal that changes in sleep and cortisol measures are associated with differential longitudinal course. Normal controls who would develop depression; after the biologic studies had shown significantly higher density of rapid eye movements (REM) and a trend for reduced REM latency compared to controls with no psychiatric disorder at follow-up. Depressed subjects with a recurrent unipolar course showed a trend towards elevated plasma cortisol near sleep onset compared to MDD subjects with no further episodes during the follow-up interval.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 474-484 |
| Number of pages | 11 |
| Journal | Biological Psychiatry |
| Volume | 40 |
| Issue number | 6 |
| DOIs | |
| State | Published - Sep 15 1996 |
| Externally published | Yes |
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Keywords
- Adolescent
- Cortisol
- Depression
- EEG sleep
- Onset
- Recurrence
ASJC Scopus subject areas
- Biological Psychiatry
Cite this
The relationship between longitudinal clinical course and sleep and cortisol changes in adolescent depression. / Rao, Uma; Dahl, Ronald E.; Ryan, Neal D.; Birmaher, Boris; Williamson, Douglas E.; Giles, Donna E.; Rao, Radhika; Kaufman, Joan; Nelson, Beverly.
In: Biological Psychiatry, Vol. 40, No. 6, 15.09.1996, p. 474-484.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The relationship between longitudinal clinical course and sleep and cortisol changes in adolescent depression
AU - Rao, Uma
AU - Dahl, Ronald E.
AU - Ryan, Neal D.
AU - Birmaher, Boris
AU - Williamson, Douglas E.
AU - Giles, Donna E.
AU - Rao, Radhika
AU - Kaufman, Joan
AU - Nelson, Beverly
PY - 1996/9/15
Y1 - 1996/9/15
N2 - This study examined the relationship between longitudinal clinical course and sleep and cortisol findings in adolescent unipolar major depressive disorder (MDD). Subjects were 28 adolescents (15.4 ± 1.3 years) systematically diagnosed with unipolar MDD and 35 group-matched normal controls who participated in EEG sleep and neuroendocrine studies. Follow-up clinical assessments were conducted 7.0 ± 0.5 years later in 94% of the original cohort. Although initial group comparisons failed to show significant differences in biologic measures, analyses incorporating clinical follow-up reveal that changes in sleep and cortisol measures are associated with differential longitudinal course. Normal controls who would develop depression; after the biologic studies had shown significantly higher density of rapid eye movements (REM) and a trend for reduced REM latency compared to controls with no psychiatric disorder at follow-up. Depressed subjects with a recurrent unipolar course showed a trend towards elevated plasma cortisol near sleep onset compared to MDD subjects with no further episodes during the follow-up interval.
AB - This study examined the relationship between longitudinal clinical course and sleep and cortisol findings in adolescent unipolar major depressive disorder (MDD). Subjects were 28 adolescents (15.4 ± 1.3 years) systematically diagnosed with unipolar MDD and 35 group-matched normal controls who participated in EEG sleep and neuroendocrine studies. Follow-up clinical assessments were conducted 7.0 ± 0.5 years later in 94% of the original cohort. Although initial group comparisons failed to show significant differences in biologic measures, analyses incorporating clinical follow-up reveal that changes in sleep and cortisol measures are associated with differential longitudinal course. Normal controls who would develop depression; after the biologic studies had shown significantly higher density of rapid eye movements (REM) and a trend for reduced REM latency compared to controls with no psychiatric disorder at follow-up. Depressed subjects with a recurrent unipolar course showed a trend towards elevated plasma cortisol near sleep onset compared to MDD subjects with no further episodes during the follow-up interval.
KW - Adolescent
KW - Cortisol
KW - Depression
KW - EEG sleep
KW - Onset
KW - Recurrence
UR - http://www.scopus.com/inward/record.url?scp=0030587417&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030587417&partnerID=8YFLogxK
U2 - 10.1016/0006-3223(95)00481-5
DO - 10.1016/0006-3223(95)00481-5
M3 - Article
C2 - 8879467
AN - SCOPUS:0030587417
VL - 40
SP - 474
EP - 484
JO - Biological Psychiatry
JF - Biological Psychiatry
SN - 0006-3223
IS - 6
ER -