The reinforcing property of ethanol in the rhesus monkey - II. Some variables related to the maintenance of intravenous ethanol-reinforced responding

Andrew J. Karoly, Gail Winger, Fumio Ikomi, James H. Woods

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

Rhesus monkeys received intravenous injections of ethanol during daily sessions contingent on their presses on an available lever. Under the standard conditions, when each response on the lever during a 3-h period each day resulted in an i.v. injection of 0.1 g/kg ethanol, the monkeys made between 30 and 50 responses/session and developed blood ethanol levels of approximately 400 mg%. Under this and other conditions of response-contingent delivery of ethanol, a negatively accelerated pattern of self-injection within sessions was demonstrated. Variations in the dose per injection (0.05-0.2 g/kg/injection) resulted in changes in the rate of lever-pressing; the number of self-injections was inversely related to dose. Ethanol intake increased only slightly with increased dose per injection. Noncontingent administration of various doses of i.v. ethanol immediately prior to a daily session decreased the number of responses; the total amount of ethanol administered (contingent plus noncontingent), however, remained constant over a pretreatment dose range of 1 to 3 g/kg. When access time to ethanol was increased from 3 to 6 h/day, the total amount of ethanol taken increased slightly. However, the blood ethanol levels at the end of a 6-h session closely approximated those obtained following 3-h sessions, indicating that during the last 3-4 h of the 6-h sessions, the rate of ethanol intake closely matched the rate of ethanol elimination.

Original languageEnglish (US)
Pages (from-to)19-25
Number of pages7
JournalPsychopharmacology
Volume58
Issue number1
DOIs
StatePublished - Jan 1978

Keywords

  • Ethanol
  • Intravenous self-administration
  • Rhesus monkey
  • Tolerance

ASJC Scopus subject areas

  • Pharmacology

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