The RAR1 interactor SGT1, an essential component of R gene-triggered disease resistance

Cristina Azevedo, Ari Sadanandom, Katsumi Kitagawa, Andreas Freialdenhoven, Ken Shirasu, Paul Schulze-Lefert

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Abstract

Plant disease resistance (R) genes trigger innate immune responses upon pathogen attack. RAR1 is an early convergence point in a signaling pathway engaged by multiple R genes. Here, we show that RAR1 interacts with plant orthologs of the yeast protein SGT1, an essential regulator in the cell cycle. Silencing the barley gene Sgt1 reveals its role in R gene-triggered, Rar1-dependent disease resistance. SGT1 associates with SKP1 and CUL1, subunits of the SCF (Skp1-Cullin-F-box) ubiquitin ligase complex. Furthermore, the RAR1-SGT1 complex also interacts with two COP9 signalosome components. The interactions among RAR1, SGT1, SCF, and signalosome subunits indicate a link between disease resistance and ubiquitination.

Original languageEnglish (US)
Pages (from-to)2073-2076
Number of pages4
JournalScience
Volume295
Issue number5562
DOIs
StatePublished - Mar 15 2002

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Azevedo, C., Sadanandom, A., Kitagawa, K., Freialdenhoven, A., Shirasu, K., & Schulze-Lefert, P. (2002). The RAR1 interactor SGT1, an essential component of R gene-triggered disease resistance. Science, 295(5562), 2073-2076. https://doi.org/10.1126/science.1067554