TY - JOUR
T1 - The RAR1 interactor SGT1, an essential component of R gene-triggered disease resistance
AU - Azevedo, Cristina
AU - Sadanandom, Ari
AU - Kitagawa, Katsumi
AU - Freialdenhoven, Andreas
AU - Shirasu, Ken
AU - Schulze-Lefert, Paul
PY - 2002/3/15
Y1 - 2002/3/15
N2 - Plant disease resistance (R) genes trigger innate immune responses upon pathogen attack. RAR1 is an early convergence point in a signaling pathway engaged by multiple R genes. Here, we show that RAR1 interacts with plant orthologs of the yeast protein SGT1, an essential regulator in the cell cycle. Silencing the barley gene Sgt1 reveals its role in R gene-triggered, Rar1-dependent disease resistance. SGT1 associates with SKP1 and CUL1, subunits of the SCF (Skp1-Cullin-F-box) ubiquitin ligase complex. Furthermore, the RAR1-SGT1 complex also interacts with two COP9 signalosome components. The interactions among RAR1, SGT1, SCF, and signalosome subunits indicate a link between disease resistance and ubiquitination.
AB - Plant disease resistance (R) genes trigger innate immune responses upon pathogen attack. RAR1 is an early convergence point in a signaling pathway engaged by multiple R genes. Here, we show that RAR1 interacts with plant orthologs of the yeast protein SGT1, an essential regulator in the cell cycle. Silencing the barley gene Sgt1 reveals its role in R gene-triggered, Rar1-dependent disease resistance. SGT1 associates with SKP1 and CUL1, subunits of the SCF (Skp1-Cullin-F-box) ubiquitin ligase complex. Furthermore, the RAR1-SGT1 complex also interacts with two COP9 signalosome components. The interactions among RAR1, SGT1, SCF, and signalosome subunits indicate a link between disease resistance and ubiquitination.
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U2 - 10.1126/science.1067554
DO - 10.1126/science.1067554
M3 - Article
C2 - 11847307
AN - SCOPUS:0037086007
SN - 0036-8075
VL - 295
SP - 2073
EP - 2076
JO - Science
JF - Science
IS - 5562
ER -