The quality of quality measures

HEDIS® quality measures for medication management in the elderly and outcomes associated with new exposure

Mary Jo V Pugh, Zachary A. Marcum, Laurel A. Copeland, Eric M. Mortensen, John E. Zeber, Polly H Noel, Dan R. Berlowitz, John R Downs, Chester B. Good, Carlos Alvarez, Megan E. Amuan, Joseph T. Hanlon

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: Clinical validation studies of the Healthcare Effectiveness Data and Information Set (HEDIS®) measures of inappropriate prescribing in the elderly are limited. Objectives: The objective of this study was to examine associations of new exposure to high-risk medication in the elderly (HRME) and drug-disease interaction (Rx-DIS) with mortality, hospital admission, and emergency care. Methods: A retrospective database study was conducted examining new use of HRME and Rx-DIS in fiscal year 2006 (Oct 2005-Sep 2006; FY06), with index date being the date of first HRME/Rx-DIS exposure, or first day of FY07 if no HRME/Rx-DIS exposure. Outcomes were assessed 1 year after the index date. The participants were veterans who were ≥65 years old in FY06 and received Veterans Health Administration (VA) care in FY05-06. A history of falls/hip fracture, chronic renal failure, and/or dementia per diagnosis codes defined the Rx-DIS subsample. The variables included a number of new unique HRME drug exposures and new unique Rx-DIS drug exposure (0, 1, >1) in FY06, and outcomes (i.e., 1-year mortality, hospital admission, and emergency care) up to 1 year after exposure. Descriptive statistics summarized variables for the overall HRME cohort and the Rx-DIS subset. Multivariable statistical analyses using generalized estimating equations (GEE) models with a logit link accounted for nesting of patients within facilities. For these latter analyses, we controlled for demographic characteristics, chronic disease states, and indicators of disease burden the previous year (e.g., number of prescriptions, emergency/hospital care). Results: Among the 1,807,404 veterans who met inclusion criteria, 5.2 % had new HRME exposure. Of the 256,388 in the Rx-DIS cohort, 3.6 % had new Rx-DIS exposure. Multivariable analyses found that HRME was significantly associated with mortality [1: adjusted odds ratio (AOR) = 1.62, 95 % CI 1.56-1.68; >1: AOR = 1.80, 95 % CI 1.45-2.23], hospital admission (1: AOR = 2.31, 95 % CI 2.22-2.40; >1: AOR = 3.44, 95 % CI 3.06-3.87), and emergency care (1: AOR = 2.59, 95 % CI 2.49-2.70; >1: AOR = 4.18, 95 % CI 3.71-4.71). Rx-DIS exposure was significantly associated with mortality (1: AOR = 1.60, 95 % CI 1.51-1.71; >1: AOR = 2.00, 95 % CI 1.38-2.91), hospital admission for one exposure (1: AOR = 1.12, 95 % CI 1.03-1.27; >1: AOR = 1.18, 95 % CI 0.71-1.95), and emergency care for two or more exposures (1: AOR = 1.06, 95 % CI 0.97-1.15; >1: AOR = 2.0, 95 % CI 1.35-3.10). Conclusions: Analyses support the link between HRME/Rx-DIS exposure and clinically significant outcomes in older veterans. Now is the time to begin incorporating input from both patients who receive these medications and providers who prescribe to develop approaches to reduce exposure to these agents.

Original languageEnglish (US)
Pages (from-to)645-654
Number of pages10
JournalDrugs and Aging
Volume30
Issue number8
DOIs
StatePublished - Aug 2013

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Quality of Health Care
Odds Ratio
Emergency Medical Services
Veterans
Hospital Mortality
Datasets
Inappropriate Prescribing
Veterans Health
Delivery of Health Care
United States Department of Veterans Affairs
Mortality
Validation Studies
Hip Fractures
Drug Interactions
Pharmaceutical Preparations
Chronic Kidney Failure
Prescriptions
Dementia
Chronic Disease
Retrospective Studies

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Geriatrics and Gerontology

Cite this

Pugh, M. J. V., Marcum, Z. A., Copeland, L. A., Mortensen, E. M., Zeber, J. E., Noel, P. H., ... Hanlon, J. T. (2013). The quality of quality measures: HEDIS® quality measures for medication management in the elderly and outcomes associated with new exposure. Drugs and Aging, 30(8), 645-654. https://doi.org/10.1007/s40266-013-0086-8

The quality of quality measures : HEDIS® quality measures for medication management in the elderly and outcomes associated with new exposure. / Pugh, Mary Jo V; Marcum, Zachary A.; Copeland, Laurel A.; Mortensen, Eric M.; Zeber, John E.; Noel, Polly H; Berlowitz, Dan R.; Downs, John R; Good, Chester B.; Alvarez, Carlos; Amuan, Megan E.; Hanlon, Joseph T.

In: Drugs and Aging, Vol. 30, No. 8, 08.2013, p. 645-654.

Research output: Contribution to journalArticle

Pugh, MJV, Marcum, ZA, Copeland, LA, Mortensen, EM, Zeber, JE, Noel, PH, Berlowitz, DR, Downs, JR, Good, CB, Alvarez, C, Amuan, ME & Hanlon, JT 2013, 'The quality of quality measures: HEDIS® quality measures for medication management in the elderly and outcomes associated with new exposure', Drugs and Aging, vol. 30, no. 8, pp. 645-654. https://doi.org/10.1007/s40266-013-0086-8
Pugh, Mary Jo V ; Marcum, Zachary A. ; Copeland, Laurel A. ; Mortensen, Eric M. ; Zeber, John E. ; Noel, Polly H ; Berlowitz, Dan R. ; Downs, John R ; Good, Chester B. ; Alvarez, Carlos ; Amuan, Megan E. ; Hanlon, Joseph T. / The quality of quality measures : HEDIS® quality measures for medication management in the elderly and outcomes associated with new exposure. In: Drugs and Aging. 2013 ; Vol. 30, No. 8. pp. 645-654.
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title = "The quality of quality measures: HEDIS{\circledR} quality measures for medication management in the elderly and outcomes associated with new exposure",
abstract = "Background: Clinical validation studies of the Healthcare Effectiveness Data and Information Set (HEDIS{\circledR}) measures of inappropriate prescribing in the elderly are limited. Objectives: The objective of this study was to examine associations of new exposure to high-risk medication in the elderly (HRME) and drug-disease interaction (Rx-DIS) with mortality, hospital admission, and emergency care. Methods: A retrospective database study was conducted examining new use of HRME and Rx-DIS in fiscal year 2006 (Oct 2005-Sep 2006; FY06), with index date being the date of first HRME/Rx-DIS exposure, or first day of FY07 if no HRME/Rx-DIS exposure. Outcomes were assessed 1 year after the index date. The participants were veterans who were ≥65 years old in FY06 and received Veterans Health Administration (VA) care in FY05-06. A history of falls/hip fracture, chronic renal failure, and/or dementia per diagnosis codes defined the Rx-DIS subsample. The variables included a number of new unique HRME drug exposures and new unique Rx-DIS drug exposure (0, 1, >1) in FY06, and outcomes (i.e., 1-year mortality, hospital admission, and emergency care) up to 1 year after exposure. Descriptive statistics summarized variables for the overall HRME cohort and the Rx-DIS subset. Multivariable statistical analyses using generalized estimating equations (GEE) models with a logit link accounted for nesting of patients within facilities. For these latter analyses, we controlled for demographic characteristics, chronic disease states, and indicators of disease burden the previous year (e.g., number of prescriptions, emergency/hospital care). Results: Among the 1,807,404 veterans who met inclusion criteria, 5.2 {\%} had new HRME exposure. Of the 256,388 in the Rx-DIS cohort, 3.6 {\%} had new Rx-DIS exposure. Multivariable analyses found that HRME was significantly associated with mortality [1: adjusted odds ratio (AOR) = 1.62, 95 {\%} CI 1.56-1.68; >1: AOR = 1.80, 95 {\%} CI 1.45-2.23], hospital admission (1: AOR = 2.31, 95 {\%} CI 2.22-2.40; >1: AOR = 3.44, 95 {\%} CI 3.06-3.87), and emergency care (1: AOR = 2.59, 95 {\%} CI 2.49-2.70; >1: AOR = 4.18, 95 {\%} CI 3.71-4.71). Rx-DIS exposure was significantly associated with mortality (1: AOR = 1.60, 95 {\%} CI 1.51-1.71; >1: AOR = 2.00, 95 {\%} CI 1.38-2.91), hospital admission for one exposure (1: AOR = 1.12, 95 {\%} CI 1.03-1.27; >1: AOR = 1.18, 95 {\%} CI 0.71-1.95), and emergency care for two or more exposures (1: AOR = 1.06, 95 {\%} CI 0.97-1.15; >1: AOR = 2.0, 95 {\%} CI 1.35-3.10). Conclusions: Analyses support the link between HRME/Rx-DIS exposure and clinically significant outcomes in older veterans. Now is the time to begin incorporating input from both patients who receive these medications and providers who prescribe to develop approaches to reduce exposure to these agents.",
author = "Pugh, {Mary Jo V} and Marcum, {Zachary A.} and Copeland, {Laurel A.} and Mortensen, {Eric M.} and Zeber, {John E.} and Noel, {Polly H} and Berlowitz, {Dan R.} and Downs, {John R} and Good, {Chester B.} and Carlos Alvarez and Amuan, {Megan E.} and Hanlon, {Joseph T.}",
year = "2013",
month = "8",
doi = "10.1007/s40266-013-0086-8",
language = "English (US)",
volume = "30",
pages = "645--654",
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TY - JOUR

T1 - The quality of quality measures

T2 - HEDIS® quality measures for medication management in the elderly and outcomes associated with new exposure

AU - Pugh, Mary Jo V

AU - Marcum, Zachary A.

AU - Copeland, Laurel A.

AU - Mortensen, Eric M.

AU - Zeber, John E.

AU - Noel, Polly H

AU - Berlowitz, Dan R.

AU - Downs, John R

AU - Good, Chester B.

AU - Alvarez, Carlos

AU - Amuan, Megan E.

AU - Hanlon, Joseph T.

PY - 2013/8

Y1 - 2013/8

N2 - Background: Clinical validation studies of the Healthcare Effectiveness Data and Information Set (HEDIS®) measures of inappropriate prescribing in the elderly are limited. Objectives: The objective of this study was to examine associations of new exposure to high-risk medication in the elderly (HRME) and drug-disease interaction (Rx-DIS) with mortality, hospital admission, and emergency care. Methods: A retrospective database study was conducted examining new use of HRME and Rx-DIS in fiscal year 2006 (Oct 2005-Sep 2006; FY06), with index date being the date of first HRME/Rx-DIS exposure, or first day of FY07 if no HRME/Rx-DIS exposure. Outcomes were assessed 1 year after the index date. The participants were veterans who were ≥65 years old in FY06 and received Veterans Health Administration (VA) care in FY05-06. A history of falls/hip fracture, chronic renal failure, and/or dementia per diagnosis codes defined the Rx-DIS subsample. The variables included a number of new unique HRME drug exposures and new unique Rx-DIS drug exposure (0, 1, >1) in FY06, and outcomes (i.e., 1-year mortality, hospital admission, and emergency care) up to 1 year after exposure. Descriptive statistics summarized variables for the overall HRME cohort and the Rx-DIS subset. Multivariable statistical analyses using generalized estimating equations (GEE) models with a logit link accounted for nesting of patients within facilities. For these latter analyses, we controlled for demographic characteristics, chronic disease states, and indicators of disease burden the previous year (e.g., number of prescriptions, emergency/hospital care). Results: Among the 1,807,404 veterans who met inclusion criteria, 5.2 % had new HRME exposure. Of the 256,388 in the Rx-DIS cohort, 3.6 % had new Rx-DIS exposure. Multivariable analyses found that HRME was significantly associated with mortality [1: adjusted odds ratio (AOR) = 1.62, 95 % CI 1.56-1.68; >1: AOR = 1.80, 95 % CI 1.45-2.23], hospital admission (1: AOR = 2.31, 95 % CI 2.22-2.40; >1: AOR = 3.44, 95 % CI 3.06-3.87), and emergency care (1: AOR = 2.59, 95 % CI 2.49-2.70; >1: AOR = 4.18, 95 % CI 3.71-4.71). Rx-DIS exposure was significantly associated with mortality (1: AOR = 1.60, 95 % CI 1.51-1.71; >1: AOR = 2.00, 95 % CI 1.38-2.91), hospital admission for one exposure (1: AOR = 1.12, 95 % CI 1.03-1.27; >1: AOR = 1.18, 95 % CI 0.71-1.95), and emergency care for two or more exposures (1: AOR = 1.06, 95 % CI 0.97-1.15; >1: AOR = 2.0, 95 % CI 1.35-3.10). Conclusions: Analyses support the link between HRME/Rx-DIS exposure and clinically significant outcomes in older veterans. Now is the time to begin incorporating input from both patients who receive these medications and providers who prescribe to develop approaches to reduce exposure to these agents.

AB - Background: Clinical validation studies of the Healthcare Effectiveness Data and Information Set (HEDIS®) measures of inappropriate prescribing in the elderly are limited. Objectives: The objective of this study was to examine associations of new exposure to high-risk medication in the elderly (HRME) and drug-disease interaction (Rx-DIS) with mortality, hospital admission, and emergency care. Methods: A retrospective database study was conducted examining new use of HRME and Rx-DIS in fiscal year 2006 (Oct 2005-Sep 2006; FY06), with index date being the date of first HRME/Rx-DIS exposure, or first day of FY07 if no HRME/Rx-DIS exposure. Outcomes were assessed 1 year after the index date. The participants were veterans who were ≥65 years old in FY06 and received Veterans Health Administration (VA) care in FY05-06. A history of falls/hip fracture, chronic renal failure, and/or dementia per diagnosis codes defined the Rx-DIS subsample. The variables included a number of new unique HRME drug exposures and new unique Rx-DIS drug exposure (0, 1, >1) in FY06, and outcomes (i.e., 1-year mortality, hospital admission, and emergency care) up to 1 year after exposure. Descriptive statistics summarized variables for the overall HRME cohort and the Rx-DIS subset. Multivariable statistical analyses using generalized estimating equations (GEE) models with a logit link accounted for nesting of patients within facilities. For these latter analyses, we controlled for demographic characteristics, chronic disease states, and indicators of disease burden the previous year (e.g., number of prescriptions, emergency/hospital care). Results: Among the 1,807,404 veterans who met inclusion criteria, 5.2 % had new HRME exposure. Of the 256,388 in the Rx-DIS cohort, 3.6 % had new Rx-DIS exposure. Multivariable analyses found that HRME was significantly associated with mortality [1: adjusted odds ratio (AOR) = 1.62, 95 % CI 1.56-1.68; >1: AOR = 1.80, 95 % CI 1.45-2.23], hospital admission (1: AOR = 2.31, 95 % CI 2.22-2.40; >1: AOR = 3.44, 95 % CI 3.06-3.87), and emergency care (1: AOR = 2.59, 95 % CI 2.49-2.70; >1: AOR = 4.18, 95 % CI 3.71-4.71). Rx-DIS exposure was significantly associated with mortality (1: AOR = 1.60, 95 % CI 1.51-1.71; >1: AOR = 2.00, 95 % CI 1.38-2.91), hospital admission for one exposure (1: AOR = 1.12, 95 % CI 1.03-1.27; >1: AOR = 1.18, 95 % CI 0.71-1.95), and emergency care for two or more exposures (1: AOR = 1.06, 95 % CI 0.97-1.15; >1: AOR = 2.0, 95 % CI 1.35-3.10). Conclusions: Analyses support the link between HRME/Rx-DIS exposure and clinically significant outcomes in older veterans. Now is the time to begin incorporating input from both patients who receive these medications and providers who prescribe to develop approaches to reduce exposure to these agents.

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