The pulmonary ultrastructure in septic shock

J. J. Coalson, L. B. Hinshaw, C. A. Guenter

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

The ultrastructural alterations in the lungs of the monkey after intravenously administered lethal injections of live E. coli organisms or endotoxin are markedly similar. Edema of the perivascular space was seen in all lung tissues examined. Pulmonary capillaries were engorged with polymorphonuclear leukocytes undergoing fragmentation 15 minutes after injections of endotoxin or E. coli organisms. The endothelial cytoplasm contained large vacuoles and many vesicles, but there was no evidence of actual rupture of the cytoplasmic membranes. Endothelial cellular membranes appeared fuzzy and indistinct at sites where polymorphonuclear leukocytes were adhering. Fragmentation and loss of specific granules in polymorphonuclear leukocytes were noted 1 hour postinjection. The loss of specific granules, fragmentation of polymorphonuclear leukocytes, and focal areas of pulmonary edema were observed 4 hours after the injection of endotoxin or live E. coli organisms. In marked contrast to a previous report on the primate administered endotoxin, this investigation revealed no evidence for intravascular coagulation of fibrin and platelet aggregates. The widespread morphological alterations could explain some of the functional derangements previously observed in monkeys in shock.

Original languageEnglish (US)
Pages (from-to)84-103
Number of pages20
JournalExperimental and Molecular Pathology
Volume12
Issue number1
DOIs
StatePublished - Feb 1970

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Clinical Biochemistry

Fingerprint Dive into the research topics of 'The pulmonary ultrastructure in septic shock'. Together they form a unique fingerprint.

  • Cite this