The Pulmonary Effect of Nitric Oxide Synthase Inhibition Following Endotoxemia in a Swine Model

Hiroshi Ogura; Patrick J. Offner; Daizo Saitoh; Bryan S. Jordan; Avery A. Johnson; Basil A. Pruitt; William G. Cioffi

doi:10.1001/archsurg.1994.01420360023002

The Pulmonary Effect of Nitric Oxide Synthase Inhibition Following Endotoxemia in a Swine Model

Hiroshi Ogura, Patrick J. Offner, Daizo Saitoh, Bryan S. Jordan, Avery A. Johnson, Basil A. Pruitt, William G. Cioffi

Department of Surgery

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Systemic NO synthase inhibition failed to restore hypoxic pulmonary vasoconstriction following LPS administration. The deleterious effects of endotoxemia on pulmonary function can be improved by inhaled NO but not by systemic inhibition of NO synthase. (Arch Surg. 1994;129:1233-1239).

Original language	English (US)
Pages (from-to)	1233-1239
Number of pages	7
Journal	Archives of Surgery
Volume	129
Issue number	12
DOIs	https://doi.org/10.1001/archsurg.1994.01420360023002
State	Published - Dec 1994

ASJC Scopus subject areas

Surgery

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10.1001/archsurg.1994.01420360023002

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title = "The Pulmonary Effect of Nitric Oxide Synthase Inhibition Following Endotoxemia in a Swine Model",

abstract = "Systemic NO synthase inhibition failed to restore hypoxic pulmonary vasoconstriction following LPS administration. The deleterious effects of endotoxemia on pulmonary function can be improved by inhaled NO but not by systemic inhibition of NO synthase. (Arch Surg. 1994;129:1233-1239).",

author = "Hiroshi Ogura and Offner, {Patrick J.} and Daizo Saitoh and Jordan, {Bryan S.} and Johnson, {Avery A.} and Pruitt, {Basil A.} and Cioffi, {William G.}",

year = "1994",

month = dec,

doi = "10.1001/archsurg.1994.01420360023002",

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AU - Ogura, Hiroshi

AU - Offner, Patrick J.

AU - Saitoh, Daizo

AU - Jordan, Bryan S.

AU - Johnson, Avery A.

AU - Pruitt, Basil A.

AU - Cioffi, William G.

PY - 1994/12

Y1 - 1994/12

N2 - Systemic NO synthase inhibition failed to restore hypoxic pulmonary vasoconstriction following LPS administration. The deleterious effects of endotoxemia on pulmonary function can be improved by inhaled NO but not by systemic inhibition of NO synthase. (Arch Surg. 1994;129:1233-1239).

AB - Systemic NO synthase inhibition failed to restore hypoxic pulmonary vasoconstriction following LPS administration. The deleterious effects of endotoxemia on pulmonary function can be improved by inhaled NO but not by systemic inhibition of NO synthase. (Arch Surg. 1994;129:1233-1239).

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The Pulmonary Effect of Nitric Oxide Synthase Inhibition Following Endotoxemia in a Swine Model

Abstract

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