The Pulmonary Effect of Nitric Oxide Synthase Inhibition Following Endotoxemia in a Swine Model

Hiroshi Ogura, Patrick J. Offner, Daizo Saitoh, Bryan S. Jordan, Avery A. Johnson, Basil A. Pruitt, William G. Cioffi

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Systemic NO synthase inhibition failed to restore hypoxic pulmonary vasoconstriction following LPS administration. The deleterious effects of endotoxemia on pulmonary function can be improved by inhaled NO but not by systemic inhibition of NO synthase. (Arch Surg. 1994;129:1233-1239).

Original languageEnglish (US)
Pages (from-to)1233-1239
Number of pages7
JournalArchives of Surgery
Volume129
Issue number12
DOIs
StatePublished - Dec 1994

ASJC Scopus subject areas

  • Surgery

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    Ogura, H., Offner, P. J., Saitoh, D., Jordan, B. S., Johnson, A. A., Pruitt, B. A., & Cioffi, W. G. (1994). The Pulmonary Effect of Nitric Oxide Synthase Inhibition Following Endotoxemia in a Swine Model. Archives of Surgery, 129(12), 1233-1239. https://doi.org/10.1001/archsurg.1994.01420360023002