The prostate cancer prevention trial: Current status and lessons learned

Ian M. Thompson, Margaret Kouril, Eric A. Klein, Charles A. Coltman, Anne Ryan, Phyllis Goodman

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

The Prostate Cancer Prevention Trial is the first phase 3 prevention trial for prostate cancer in the United States. The implementation of a large, randomized trial has provided a wealth of information that will aid in future cancer chemopreventive studies in US men. The experience from the implementation of the Prostate Cancer Prevention Trial was reviewed. Lessons learned from the study include: (1) US men are willing to enroll in prevention trials; (2) participants in chemoprevention trials are well educated and healthy; (3) the successful cancer prevention trial is viewed by participants as a “men's health trial”; (4) data management and discipline coordination at participating institutions are critical; (5) study design change is commonly required owing to changes in clinical practice over the course of the trial; and (6) training of institutional staff is essential. With proper design, robust data management, and a flexible staff, large-scale randomized chemoprevention trials can be accomplished in the United States. With the extraordinary number ofpotential agents, it is expected that much will be accomplished with this strategy in the near future.

Original languageEnglish (US)
Pages (from-to)230-234
Number of pages5
JournalUrology
Volume57
Issue number4
DOIs
StatePublished - Jan 1 2001

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ASJC Scopus subject areas

  • Urology

Cite this

Thompson, I. M., Kouril, M., Klein, E. A., Coltman, C. A., Ryan, A., & Goodman, P. (2001). The prostate cancer prevention trial: Current status and lessons learned. Urology, 57(4), 230-234. https://doi.org/10.1016/S0090-4295(00)00980-8