The proopiocortin (adrenocorticotropin/β-lipotropin) gene is located on chromosome 2 in humans

David Owerbach, William J. Rutter, James L. Roberts, Peter Whitfeld, John Shine, Peter H. Seeburg, Thomas B. Shows

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

The proopiocortin gene is located on chromosome 2 in humans. A 13-kb DNA fragment containing proopiocortin gene sequences was identified in human cells while proopiocortin-related gene sequences of 9.8 and 6.2 kb were present in mouse cells. In human-mouse cell hybrids which contained reduced numbers of human chromosomes and a complete set of mouse chromosomes, the 9.8- and 6.2-kb fragments were always present while the 13-kb fragment segregated with human chromosome 2 and the chromosome 2 enzyme markers acid phosphatase-1 (ACP1), malate dehydrogenase-1 (MDH1), and isocitrate dehydrogenase-1 (IDH1). Analysis of a single cell hybrid with a broken chromosome 2 indicates that the proopiocortin and ACP1 genes are closely linked and in the distal region of the short arm of chromosome 2.

Original languageEnglish (US)
Pages (from-to)359-369
Number of pages11
JournalSomatic Cell Genetics
Volume7
Issue number3
DOIs
StatePublished - May 1981
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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