The prolactin response to fenfluramine in schizophrenia is associated with negative symptoms

Rajiv P. Sharma, Vivek Singh, Philip G. Janicak, Javaid I. Javaid, Ghanshyam N. Pandey

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

We examined the serotonergic system in drug-free inpatients [schizophrenia (n=28) and schizoaffective (n=7)] by administering a challenge dose of oral dl-fenfluramine (fenfluramine) in a controlled angiocatheter study. Seventeen of these patients were also randomized to a placebo condition in addition to receiving fenfluramine. Response to fenfluramine as reflected by changes in serum prolactin and cortisol were examined by repeated measures ANOVA, as well as Area Under the Curves (AUCs). The prolactin response, but not the cortisol response, was significantly correlated with measures of negative symptoms. (C) 1999 Elsevier Science B.V. All rights reserved.

Original languageEnglish (US)
Pages (from-to)85-89
Number of pages5
JournalSchizophrenia research
Volume39
Issue number1
DOIs
StatePublished - Aug 23 1999

Keywords

  • Cortisol
  • Fenfluramine
  • Negative symptoms
  • Prolactin
  • Schizoaffectve disorders
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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