Abstract
We examined the serotonergic system in drug-free inpatients [schizophrenia (n=28) and schizoaffective (n=7)] by administering a challenge dose of oral dl-fenfluramine (fenfluramine) in a controlled angiocatheter study. Seventeen of these patients were also randomized to a placebo condition in addition to receiving fenfluramine. Response to fenfluramine as reflected by changes in serum prolactin and cortisol were examined by repeated measures ANOVA, as well as Area Under the Curves (AUCs). The prolactin response, but not the cortisol response, was significantly correlated with measures of negative symptoms. (C) 1999 Elsevier Science B.V. All rights reserved.
Original language | English (US) |
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Pages (from-to) | 85-89 |
Number of pages | 5 |
Journal | Schizophrenia research |
Volume | 39 |
Issue number | 1 |
DOIs | |
State | Published - Aug 23 1999 |
Keywords
- Cortisol
- Fenfluramine
- Negative symptoms
- Prolactin
- Schizoaffectve disorders
- Schizophrenia
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry