The prolactin response to fenfluramine in schizophrenia is associated with negative symptoms

Rajiv P. Sharma; Vivek Singh; Philip G. Janicak; Javaid I. Javaid; Ghanshyam N. Pandey

doi:10.1016/S0920-9964(99)00014-6

The prolactin response to fenfluramine in schizophrenia is associated with negative symptoms

Rajiv P. Sharma, Vivek Singh, Philip G. Janicak, Javaid I. Javaid, Ghanshyam N. Pandey

Department of Psychiatry & Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

We examined the serotonergic system in drug-free inpatients [schizophrenia (n=28) and schizoaffective (n=7)] by administering a challenge dose of oral dl-fenfluramine (fenfluramine) in a controlled angiocatheter study. Seventeen of these patients were also randomized to a placebo condition in addition to receiving fenfluramine. Response to fenfluramine as reflected by changes in serum prolactin and cortisol were examined by repeated measures ANOVA, as well as Area Under the Curves (AUCs). The prolactin response, but not the cortisol response, was significantly correlated with measures of negative symptoms. (C) 1999 Elsevier Science B.V. All rights reserved.

Original language	English (US)
Pages (from-to)	85-89
Number of pages	5
Journal	Schizophrenia research
Volume	39
Issue number	1
DOIs	https://doi.org/10.1016/S0920-9964(99)00014-6
State	Published - Aug 23 1999

Keywords

Cortisol
Fenfluramine
Negative symptoms
Prolactin
Schizoaffectve disorders
Schizophrenia

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/S0920-9964(99)00014-6

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title = "The prolactin response to fenfluramine in schizophrenia is associated with negative symptoms",

abstract = "We examined the serotonergic system in drug-free inpatients [schizophrenia (n=28) and schizoaffective (n=7)] by administering a challenge dose of oral dl-fenfluramine (fenfluramine) in a controlled angiocatheter study. Seventeen of these patients were also randomized to a placebo condition in addition to receiving fenfluramine. Response to fenfluramine as reflected by changes in serum prolactin and cortisol were examined by repeated measures ANOVA, as well as Area Under the Curves (AUCs). The prolactin response, but not the cortisol response, was significantly correlated with measures of negative symptoms. (C) 1999 Elsevier Science B.V. All rights reserved.",

keywords = "Cortisol, Fenfluramine, Negative symptoms, Prolactin, Schizoaffectve disorders, Schizophrenia",

author = "Sharma, {Rajiv P.} and Vivek Singh and Janicak, {Philip G.} and Javaid, {Javaid I.} and Pandey, {Ghanshyam N.}",

note = "Funding Information: This study was supported by MH-48888 to R.P.S. We thank Nijole Grazulis M.S., for editorial assistance. ",

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AU - Sharma, Rajiv P.

AU - Singh, Vivek

AU - Janicak, Philip G.

AU - Javaid, Javaid I.

AU - Pandey, Ghanshyam N.

N1 - Funding Information: This study was supported by MH-48888 to R.P.S. We thank Nijole Grazulis M.S., for editorial assistance.

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N2 - We examined the serotonergic system in drug-free inpatients [schizophrenia (n=28) and schizoaffective (n=7)] by administering a challenge dose of oral dl-fenfluramine (fenfluramine) in a controlled angiocatheter study. Seventeen of these patients were also randomized to a placebo condition in addition to receiving fenfluramine. Response to fenfluramine as reflected by changes in serum prolactin and cortisol were examined by repeated measures ANOVA, as well as Area Under the Curves (AUCs). The prolactin response, but not the cortisol response, was significantly correlated with measures of negative symptoms. (C) 1999 Elsevier Science B.V. All rights reserved.

AB - We examined the serotonergic system in drug-free inpatients [schizophrenia (n=28) and schizoaffective (n=7)] by administering a challenge dose of oral dl-fenfluramine (fenfluramine) in a controlled angiocatheter study. Seventeen of these patients were also randomized to a placebo condition in addition to receiving fenfluramine. Response to fenfluramine as reflected by changes in serum prolactin and cortisol were examined by repeated measures ANOVA, as well as Area Under the Curves (AUCs). The prolactin response, but not the cortisol response, was significantly correlated with measures of negative symptoms. (C) 1999 Elsevier Science B.V. All rights reserved.

KW - Cortisol

KW - Fenfluramine

KW - Negative symptoms

KW - Prolactin

KW - Schizoaffectve disorders

KW - Schizophrenia

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The prolactin response to fenfluramine in schizophrenia is associated with negative symptoms

Abstract

Keywords

ASJC Scopus subject areas

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