The Pro12Ala variant of peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) is associated with measures of obesity in Mexican Americans

Shelly A. Cole, B. D. Mitchell, W. C. Hsueh, P. Pineda, B. A. Beamer, A. R. Shuldiner, A. G. Comuzzie, J. Blangero, J. E. Hixson

Research output: Contribution to journalArticle

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Abstract

Peroxisome proliferator-activated receptors (PPAR) are transcription factors that regulate adipocyte differentiation and gene expression. We tested the hypothesis that the Pro12Ala variant of PPAR-γ2 is associated with obesity and type 2 diabetes-related traits in 921 subjects from the San Antonio Family Heart Study. Subjects with at least one Ala allele (n = 210) had significantly higher body mass index (P = 0.015) and waist circumference (P = 0.028) and significantly higher levels of serum leptin (P = 0.022) than those without the allele. Further studies will determine whether the Pro12Ala variant itself, or other genetic variation at PPAR-γ, is responsible for this association with measures of obesity in Mexican Americans.

Original languageEnglish (US)
Pages (from-to)522-524
Number of pages3
JournalInternational Journal of Obesity
Volume24
Issue number4
StatePublished - 2000
Externally publishedYes

Fingerprint

Mexican Americans
Peroxisome Proliferator-Activated Receptors
obesity
Obesity
Alleles
alleles
waist circumference
Waist Circumference
Leptin
leptin
adipocytes
noninsulin-dependent diabetes mellitus
Adipocytes
Type 2 Diabetes Mellitus
body mass index
Body Mass Index
Transcription Factors
transcription factors
heart
Gene Expression

Keywords

  • BMI
  • Leptin
  • Obesity
  • PPAR-γ

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Endocrinology
  • Food Science
  • Endocrinology, Diabetes and Metabolism

Cite this

Cole, S. A., Mitchell, B. D., Hsueh, W. C., Pineda, P., Beamer, B. A., Shuldiner, A. R., ... Hixson, J. E. (2000). The Pro12Ala variant of peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) is associated with measures of obesity in Mexican Americans. International Journal of Obesity, 24(4), 522-524.

The Pro12Ala variant of peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) is associated with measures of obesity in Mexican Americans. / Cole, Shelly A.; Mitchell, B. D.; Hsueh, W. C.; Pineda, P.; Beamer, B. A.; Shuldiner, A. R.; Comuzzie, A. G.; Blangero, J.; Hixson, J. E.

In: International Journal of Obesity, Vol. 24, No. 4, 2000, p. 522-524.

Research output: Contribution to journalArticle

Cole, SA, Mitchell, BD, Hsueh, WC, Pineda, P, Beamer, BA, Shuldiner, AR, Comuzzie, AG, Blangero, J & Hixson, JE 2000, 'The Pro12Ala variant of peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) is associated with measures of obesity in Mexican Americans', International Journal of Obesity, vol. 24, no. 4, pp. 522-524.
Cole, Shelly A. ; Mitchell, B. D. ; Hsueh, W. C. ; Pineda, P. ; Beamer, B. A. ; Shuldiner, A. R. ; Comuzzie, A. G. ; Blangero, J. ; Hixson, J. E. / The Pro12Ala variant of peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) is associated with measures of obesity in Mexican Americans. In: International Journal of Obesity. 2000 ; Vol. 24, No. 4. pp. 522-524.
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