The Pro12Ala variant of peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) is associated with measures of obesity in Mexican Americans

Shelly A. Cole, B. D. Mitchell, W. C. Hsueh, P. Pineda, B. A. Beamer, A. R. Shuldiner, A. G. Comuzzie, J. Blangero, J. E. Hixson

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    92 Scopus citations

    Abstract

    Peroxisome proliferator-activated receptors (PPAR) are transcription factors that regulate adipocyte differentiation and gene expression. We tested the hypothesis that the Pro12Ala variant of PPAR-γ2 is associated with obesity and type 2 diabetes-related traits in 921 subjects from the San Antonio Family Heart Study. Subjects with at least one Ala allele (n = 210) had significantly higher body mass index (P = 0.015) and waist circumference (P = 0.028) and significantly higher levels of serum leptin (P = 0.022) than those without the allele. Further studies will determine whether the Pro12Ala variant itself, or other genetic variation at PPAR-γ, is responsible for this association with measures of obesity in Mexican Americans.

    Original languageEnglish (US)
    Pages (from-to)522-524
    Number of pages3
    JournalInternational Journal of Obesity
    Volume24
    Issue number4
    DOIs
    StatePublished - Jan 1 2000

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    Keywords

    • BMI
    • Leptin
    • Obesity
    • PPAR-γ

    ASJC Scopus subject areas

    • Medicine (miscellaneous)
    • Endocrinology, Diabetes and Metabolism
    • Nutrition and Dietetics

    Cite this

    Cole, S. A., Mitchell, B. D., Hsueh, W. C., Pineda, P., Beamer, B. A., Shuldiner, A. R., Comuzzie, A. G., Blangero, J., & Hixson, J. E. (2000). The Pro12Ala variant of peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) is associated with measures of obesity in Mexican Americans. International Journal of Obesity, 24(4), 522-524. https://doi.org/10.1038/sj.ijo.0801210