Abstract
Peroxisome proliferator-activated receptors (PPAR) are transcription factors that regulate adipocyte differentiation and gene expression. We tested the hypothesis that the Pro12Ala variant of PPAR-γ2 is associated with obesity and type 2 diabetes-related traits in 921 subjects from the San Antonio Family Heart Study. Subjects with at least one Ala allele (n = 210) had significantly higher body mass index (P = 0.015) and waist circumference (P = 0.028) and significantly higher levels of serum leptin (P = 0.022) than those without the allele. Further studies will determine whether the Pro12Ala variant itself, or other genetic variation at PPAR-γ, is responsible for this association with measures of obesity in Mexican Americans.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 522-524 |
| Number of pages | 3 |
| Journal | International Journal of Obesity |
| Volume | 24 |
| Issue number | 4 |
| State | Published - 2000 |
| Externally published | Yes |
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Keywords
- BMI
- Leptin
- Obesity
- PPAR-γ
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Public Health, Environmental and Occupational Health
- Endocrinology
- Food Science
- Endocrinology, Diabetes and Metabolism
Cite this
The Pro12Ala variant of peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) is associated with measures of obesity in Mexican Americans. / Cole, Shelly A.; Mitchell, B. D.; Hsueh, W. C.; Pineda, P.; Beamer, B. A.; Shuldiner, A. R.; Comuzzie, A. G.; Blangero, J.; Hixson, J. E.
In: International Journal of Obesity, Vol. 24, No. 4, 2000, p. 522-524.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The Pro12Ala variant of peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) is associated with measures of obesity in Mexican Americans
AU - Cole, Shelly A.
AU - Mitchell, B. D.
AU - Hsueh, W. C.
AU - Pineda, P.
AU - Beamer, B. A.
AU - Shuldiner, A. R.
AU - Comuzzie, A. G.
AU - Blangero, J.
AU - Hixson, J. E.
PY - 2000
Y1 - 2000
N2 - Peroxisome proliferator-activated receptors (PPAR) are transcription factors that regulate adipocyte differentiation and gene expression. We tested the hypothesis that the Pro12Ala variant of PPAR-γ2 is associated with obesity and type 2 diabetes-related traits in 921 subjects from the San Antonio Family Heart Study. Subjects with at least one Ala allele (n = 210) had significantly higher body mass index (P = 0.015) and waist circumference (P = 0.028) and significantly higher levels of serum leptin (P = 0.022) than those without the allele. Further studies will determine whether the Pro12Ala variant itself, or other genetic variation at PPAR-γ, is responsible for this association with measures of obesity in Mexican Americans.
AB - Peroxisome proliferator-activated receptors (PPAR) are transcription factors that regulate adipocyte differentiation and gene expression. We tested the hypothesis that the Pro12Ala variant of PPAR-γ2 is associated with obesity and type 2 diabetes-related traits in 921 subjects from the San Antonio Family Heart Study. Subjects with at least one Ala allele (n = 210) had significantly higher body mass index (P = 0.015) and waist circumference (P = 0.028) and significantly higher levels of serum leptin (P = 0.022) than those without the allele. Further studies will determine whether the Pro12Ala variant itself, or other genetic variation at PPAR-γ, is responsible for this association with measures of obesity in Mexican Americans.
KW - BMI
KW - Leptin
KW - Obesity
KW - PPAR-γ
UR - http://www.scopus.com/inward/record.url?scp=0034076458&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034076458&partnerID=8YFLogxK
M3 - Article
VL - 24
SP - 522
EP - 524
JO - International Journal of Obesity
JF - International Journal of Obesity
SN - 0307-0565
IS - 4
ER -