The Pro12Ala variant of peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) is associated with measures of obesity in Mexican Americans

Shelly A. Cole; B. D. Mitchell; W. C. Hsueh; P. Pineda; B. A. Beamer; A. R. Shuldiner; A. G. Comuzzie; J. Blangero; J. E. Hixson

doi:10.1038/sj.ijo.0801210

The Pro12Ala variant of peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) is associated with measures of obesity in Mexican Americans

Shelly A. Cole, B. D. Mitchell, W. C. Hsueh, P. Pineda, B. A. Beamer, A. R. Shuldiner, A. G. Comuzzie, J. Blangero, J. E. Hixson

Research output: Contribution to journal › Article › peer-review

93 Scopus citations

Abstract

Peroxisome proliferator-activated receptors (PPAR) are transcription factors that regulate adipocyte differentiation and gene expression. We tested the hypothesis that the Pro12Ala variant of PPAR-γ2 is associated with obesity and type 2 diabetes-related traits in 921 subjects from the San Antonio Family Heart Study. Subjects with at least one Ala allele (n = 210) had significantly higher body mass index (P = 0.015) and waist circumference (P = 0.028) and significantly higher levels of serum leptin (P = 0.022) than those without the allele. Further studies will determine whether the Pro12Ala variant itself, or other genetic variation at PPAR-γ, is responsible for this association with measures of obesity in Mexican Americans.

Original language	English (US)
Pages (from-to)	522-524
Number of pages	3
Journal	International Journal of Obesity
Volume	24
Issue number	4
DOIs	https://doi.org/10.1038/sj.ijo.0801210
State	Published - 2000

Keywords

BMI
Leptin
Obesity
PPAR-γ

ASJC Scopus subject areas

Medicine (miscellaneous)
Endocrinology, Diabetes and Metabolism
Nutrition and Dietetics

Access to Document

10.1038/sj.ijo.0801210

Fingerprint Dive into the research topics of 'The Pro12Ala variant of peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) is associated with measures of obesity in Mexican Americans'. Together they form a unique fingerprint.

Cite this

Cole, S. A., Mitchell, B. D., Hsueh, W. C., Pineda, P., Beamer, B. A., Shuldiner, A. R., Comuzzie, A. G., Blangero, J., & Hixson, J. E. (2000). The Pro12Ala variant of peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) is associated with measures of obesity in Mexican Americans. International Journal of Obesity, 24(4), 522-524. https://doi.org/10.1038/sj.ijo.0801210

The Pro12Ala variant of peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) is associated with measures of obesity in Mexican Americans. / Cole, Shelly A.; Mitchell, B. D.; Hsueh, W. C.; Pineda, P.; Beamer, B. A.; Shuldiner, A. R.; Comuzzie, A. G.; Blangero, J.; Hixson, J. E.

In: International Journal of Obesity, Vol. 24, No. 4, 2000, p. 522-524.

Research output: Contribution to journal › Article › peer-review

@article{cb9d449846c9494fa35df62dd7a49e8a,

title = "The Pro12Ala variant of peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) is associated with measures of obesity in Mexican Americans",

abstract = "Peroxisome proliferator-activated receptors (PPAR) are transcription factors that regulate adipocyte differentiation and gene expression. We tested the hypothesis that the Pro12Ala variant of PPAR-γ2 is associated with obesity and type 2 diabetes-related traits in 921 subjects from the San Antonio Family Heart Study. Subjects with at least one Ala allele (n = 210) had significantly higher body mass index (P = 0.015) and waist circumference (P = 0.028) and significantly higher levels of serum leptin (P = 0.022) than those without the allele. Further studies will determine whether the Pro12Ala variant itself, or other genetic variation at PPAR-γ, is responsible for this association with measures of obesity in Mexican Americans.",

keywords = "BMI, Leptin, Obesity, PPAR-γ",

author = "Cole, {Shelly A.} and Mitchell, {B. D.} and Hsueh, {W. C.} and P. Pineda and Beamer, {B. A.} and Shuldiner, {A. R.} and Comuzzie, {A. G.} and J. Blangero and Hixson, {J. E.}",

note = "Funding Information: We are deeply grateful for the cooperation of the SAFHS participants. This work was supported by National Institutes of Health research grants PO1-HL45522 and RO1-AR43351. Support for the Frederic C. Bartter General Clinical Research Center was through Clinical National Institutes of Health Grant MO1-RR-01346.",

year = "2000",

doi = "10.1038/sj.ijo.0801210",

language = "English (US)",

volume = "24",

pages = "522--524",

journal = "International Journal of Obesity",

issn = "0307-0565",

publisher = "Nature Publishing Group",

number = "4",

}

TY - JOUR

T1 - The Pro12Ala variant of peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) is associated with measures of obesity in Mexican Americans

AU - Cole, Shelly A.

AU - Mitchell, B. D.

AU - Hsueh, W. C.

AU - Pineda, P.

AU - Beamer, B. A.

AU - Shuldiner, A. R.

AU - Comuzzie, A. G.

AU - Blangero, J.

AU - Hixson, J. E.

N1 - Funding Information: We are deeply grateful for the cooperation of the SAFHS participants. This work was supported by National Institutes of Health research grants PO1-HL45522 and RO1-AR43351. Support for the Frederic C. Bartter General Clinical Research Center was through Clinical National Institutes of Health Grant MO1-RR-01346.

PY - 2000

Y1 - 2000

N2 - Peroxisome proliferator-activated receptors (PPAR) are transcription factors that regulate adipocyte differentiation and gene expression. We tested the hypothesis that the Pro12Ala variant of PPAR-γ2 is associated with obesity and type 2 diabetes-related traits in 921 subjects from the San Antonio Family Heart Study. Subjects with at least one Ala allele (n = 210) had significantly higher body mass index (P = 0.015) and waist circumference (P = 0.028) and significantly higher levels of serum leptin (P = 0.022) than those without the allele. Further studies will determine whether the Pro12Ala variant itself, or other genetic variation at PPAR-γ, is responsible for this association with measures of obesity in Mexican Americans.

AB - Peroxisome proliferator-activated receptors (PPAR) are transcription factors that regulate adipocyte differentiation and gene expression. We tested the hypothesis that the Pro12Ala variant of PPAR-γ2 is associated with obesity and type 2 diabetes-related traits in 921 subjects from the San Antonio Family Heart Study. Subjects with at least one Ala allele (n = 210) had significantly higher body mass index (P = 0.015) and waist circumference (P = 0.028) and significantly higher levels of serum leptin (P = 0.022) than those without the allele. Further studies will determine whether the Pro12Ala variant itself, or other genetic variation at PPAR-γ, is responsible for this association with measures of obesity in Mexican Americans.

KW - BMI

KW - Leptin

KW - Obesity

KW - PPAR-γ

UR - http://www.scopus.com/inward/record.url?scp=0034076458&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034076458&partnerID=8YFLogxK

U2 - 10.1038/sj.ijo.0801210

DO - 10.1038/sj.ijo.0801210

M3 - Article

C2 - 10805513

AN - SCOPUS:0034076458

VL - 24

SP - 522

EP - 524

JO - International Journal of Obesity

JF - International Journal of Obesity

SN - 0307-0565

IS - 4

ER -