The Pro12Ala variant of peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) is associated with measures of obesity in Mexican Americans

Shelly A. Cole; B. D. Mitchell; W. C. Hsueh; P. Pineda; B. A. Beamer; A. R. Shuldiner; A. G. Comuzzie; J. Blangero; J. E. Hixson

doi:10.1038/sj.ijo.0801210

The Pro12Ala variant of peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) is associated with measures of obesity in Mexican Americans

Shelly A. Cole, B. D. Mitchell, W. C. Hsueh, P. Pineda, B. A. Beamer, A. R. Shuldiner, A. G. Comuzzie, J. Blangero, J. E. Hixson

Research output: Contribution to journal › Article

92 Scopus citations

Abstract

Peroxisome proliferator-activated receptors (PPAR) are transcription factors that regulate adipocyte differentiation and gene expression. We tested the hypothesis that the Pro12Ala variant of PPAR-γ2 is associated with obesity and type 2 diabetes-related traits in 921 subjects from the San Antonio Family Heart Study. Subjects with at least one Ala allele (n = 210) had significantly higher body mass index (P = 0.015) and waist circumference (P = 0.028) and significantly higher levels of serum leptin (P = 0.022) than those without the allele. Further studies will determine whether the Pro12Ala variant itself, or other genetic variation at PPAR-γ, is responsible for this association with measures of obesity in Mexican Americans.

Original language	English (US)
Pages (from-to)	522-524
Number of pages	3
Journal	International Journal of Obesity
Volume	24
Issue number	4
DOIs	https://doi.org/10.1038/sj.ijo.0801210
State	Published - Jan 1 2000

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Keywords

BMI
Leptin
Obesity
PPAR-γ

ASJC Scopus subject areas

Medicine (miscellaneous)
Endocrinology, Diabetes and Metabolism
Nutrition and Dietetics

Cite this

Cole, S. A., Mitchell, B. D., Hsueh, W. C., Pineda, P., Beamer, B. A., Shuldiner, A. R., Comuzzie, A. G., Blangero, J., & Hixson, J. E. (2000). The Pro12Ala variant of peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) is associated with measures of obesity in Mexican Americans. International Journal of Obesity, 24(4), 522-524. https://doi.org/10.1038/sj.ijo.0801210

The Pro12Ala variant of peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) is associated with measures of obesity in Mexican Americans. / Cole, Shelly A.; Mitchell, B. D.; Hsueh, W. C.; Pineda, P.; Beamer, B. A.; Shuldiner, A. R.; Comuzzie, A. G.; Blangero, J.; Hixson, J. E.

In: International Journal of Obesity, Vol. 24, No. 4, 01.01.2000, p. 522-524.

Research output: Contribution to journal › Article

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10.1038/sj.ijo.0801210