The Pro12Ala variant of peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) is associated with measures of obesity in Mexican Americans

Shelly A. Cole; B. D. Mitchell; W. C. Hsueh; P. Pineda; B. A. Beamer; A. R. Shuldiner; A. G. Comuzzie; J. Blangero; J. E. Hixson

doi:10.1038/sj.ijo.0801210

The Pro12Ala variant of peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) is associated with measures of obesity in Mexican Americans

Shelly A. Cole, B. D. Mitchell, W. C. Hsueh, P. Pineda, B. A. Beamer, A. R. Shuldiner, A. G. Comuzzie, J. Blangero, J. E. Hixson

Research output: Contribution to journal › Article › peer-review

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Abstract

Peroxisome proliferator-activated receptors (PPAR) are transcription factors that regulate adipocyte differentiation and gene expression. We tested the hypothesis that the Pro12Ala variant of PPAR-γ2 is associated with obesity and type 2 diabetes-related traits in 921 subjects from the San Antonio Family Heart Study. Subjects with at least one Ala allele (n = 210) had significantly higher body mass index (P = 0.015) and waist circumference (P = 0.028) and significantly higher levels of serum leptin (P = 0.022) than those without the allele. Further studies will determine whether the Pro12Ala variant itself, or other genetic variation at PPAR-γ, is responsible for this association with measures of obesity in Mexican Americans.

Original language	English (US)
Pages (from-to)	522-524
Number of pages	3
Journal	International Journal of Obesity
Volume	24
Issue number	4
DOIs	https://doi.org/10.1038/sj.ijo.0801210
State	Published - 2000
Externally published	Yes

Keywords

BMI
Leptin
Obesity
PPAR-γ

ASJC Scopus subject areas

Medicine (miscellaneous)
Endocrinology, Diabetes and Metabolism
Nutrition and Dietetics

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Cole, S. A., Mitchell, B. D., Hsueh, W. C., Pineda, P., Beamer, B. A., Shuldiner, A. R., Comuzzie, A. G., Blangero, J., & Hixson, J. E. (2000). The Pro12Ala variant of peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) is associated with measures of obesity in Mexican Americans. International Journal of Obesity, 24(4), 522-524. https://doi.org/10.1038/sj.ijo.0801210

The Pro12Ala variant of peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) is associated with measures of obesity in Mexican Americans. / Cole, Shelly A.; Mitchell, B. D.; Hsueh, W. C.; Pineda, P.; Beamer, B. A.; Shuldiner, A. R.; Comuzzie, A. G.; Blangero, J.; Hixson, J. E.

In: International Journal of Obesity, Vol. 24, No. 4, 2000, p. 522-524.

Research output: Contribution to journal › Article › peer-review

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abstract = "Peroxisome proliferator-activated receptors (PPAR) are transcription factors that regulate adipocyte differentiation and gene expression. We tested the hypothesis that the Pro12Ala variant of PPAR-γ2 is associated with obesity and type 2 diabetes-related traits in 921 subjects from the San Antonio Family Heart Study. Subjects with at least one Ala allele (n = 210) had significantly higher body mass index (P = 0.015) and waist circumference (P = 0.028) and significantly higher levels of serum leptin (P = 0.022) than those without the allele. Further studies will determine whether the Pro12Ala variant itself, or other genetic variation at PPAR-γ, is responsible for this association with measures of obesity in Mexican Americans.",

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author = "Cole, {Shelly A.} and Mitchell, {B. D.} and Hsueh, {W. C.} and P. Pineda and Beamer, {B. A.} and Shuldiner, {A. R.} and Comuzzie, {A. G.} and J. Blangero and Hixson, {J. E.}",

note = "Funding Information: We are deeply grateful for the cooperation of the SAFHS participants. This work was supported by National Institutes of Health research grants PO1-HL45522 and RO1-AR43351. Support for the Frederic C. Bartter General Clinical Research Center was through Clinical National Institutes of Health Grant MO1-RR-01346. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

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doi = "10.1038/sj.ijo.0801210",

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AU - Mitchell, B. D.

AU - Hsueh, W. C.

AU - Pineda, P.

AU - Beamer, B. A.

AU - Shuldiner, A. R.

AU - Comuzzie, A. G.

AU - Blangero, J.

AU - Hixson, J. E.

N1 - Funding Information: We are deeply grateful for the cooperation of the SAFHS participants. This work was supported by National Institutes of Health research grants PO1-HL45522 and RO1-AR43351. Support for the Frederic C. Bartter General Clinical Research Center was through Clinical National Institutes of Health Grant MO1-RR-01346. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 2000

Y1 - 2000

N2 - Peroxisome proliferator-activated receptors (PPAR) are transcription factors that regulate adipocyte differentiation and gene expression. We tested the hypothesis that the Pro12Ala variant of PPAR-γ2 is associated with obesity and type 2 diabetes-related traits in 921 subjects from the San Antonio Family Heart Study. Subjects with at least one Ala allele (n = 210) had significantly higher body mass index (P = 0.015) and waist circumference (P = 0.028) and significantly higher levels of serum leptin (P = 0.022) than those without the allele. Further studies will determine whether the Pro12Ala variant itself, or other genetic variation at PPAR-γ, is responsible for this association with measures of obesity in Mexican Americans.

AB - Peroxisome proliferator-activated receptors (PPAR) are transcription factors that regulate adipocyte differentiation and gene expression. We tested the hypothesis that the Pro12Ala variant of PPAR-γ2 is associated with obesity and type 2 diabetes-related traits in 921 subjects from the San Antonio Family Heart Study. Subjects with at least one Ala allele (n = 210) had significantly higher body mass index (P = 0.015) and waist circumference (P = 0.028) and significantly higher levels of serum leptin (P = 0.022) than those without the allele. Further studies will determine whether the Pro12Ala variant itself, or other genetic variation at PPAR-γ, is responsible for this association with measures of obesity in Mexican Americans.

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The Pro12Ala variant of peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) is associated with measures of obesity in Mexican Americans

Abstract

Keywords

ASJC Scopus subject areas

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