The primate spinal cord is a target for gonadal steroids

Peter J. Sheridan, Frank J. Weaker

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

The nuclear uptake and retention of3H-dihydrotestosterone (3H-DHT) or one of its metabolites was studied in the spinal cord of the rhesus monkey. Normally-cycling adult female rhesus monkeys which were castrated and adre- nalectomized prior to the experiment were injected with 1 μg of3 H-DHT (107 Ci/mmole)/kg body weight and killed 90 minutes later. The spinal cords were removed and segments processed for autoradiography. Nuclear uptake and retention were found in both the visceral and somatic motor systems and, in addition, in the nociceptive system. The data suggest a role for androgen in sexual reflexes and possibly pain perception at the level of the spinal cord in the primate and provide further support for a role of androgen in amyotrophic lateral sclerosis.

Original languageEnglish (US)
Pages (from-to)447-453
Number of pages7
JournalJournal of Neuropathology and Experimental Neurology
Volume40
Issue number4
DOIs
StatePublished - Jul 1981

Keywords

  • Androgen-receptor
  • Autoradiography
  • Nuclear-uptake-retention
  • Primates
  • Spinal cord

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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