The potential utility of melatonin in the treatment of childhood cancer

Yu Hua Chao; Kang Hsi Wu; Chia Ming Yeh; Shih Chi Su; Russel J. Reiter; Shun Fa Yang

doi:10.1002/jcp.28566

The potential utility of melatonin in the treatment of childhood cancer

Yu Hua Chao, Kang Hsi Wu, Chia Ming Yeh, Shih Chi Su, Russel J. Reiter, Shun Fa Yang

Department of Cell Systems & Anatomy

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

Childhood cancer management has improved considerably, with the overall objective of preventing early-life cancers completely. However, cancer remains a major cause of death in children, with the survivors developing anticancer treatment-specific health problems. Therefore, the anticancer treatment needs further improvement. Melatonin is a effective antioxidant and circadian pacemaker. Through multiple mechanisms, melatonin has significant positive effects on multitude adult cancers by increasing survival and treatment response rates, and slowing disease progression. In addition, melatonin appears to be safe for children. As an appealing therapeutic agent, we herein address several key concerns regarding melatonin's potential for treating children with cancer.

Original language	English (US)
Pages (from-to)	19158-19166
Number of pages	9
Journal	Journal of Cellular Physiology
Volume	234
Issue number	11
DOIs	https://doi.org/10.1002/jcp.28566
State	Published - Nov 2019

Keywords

antioxidant
childhood cancer
melatonin
therapeutic agent

ASJC Scopus subject areas

Physiology
Clinical Biochemistry
Cell Biology

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10.1002/jcp.28566

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title = "The potential utility of melatonin in the treatment of childhood cancer",

abstract = "Childhood cancer management has improved considerably, with the overall objective of preventing early-life cancers completely. However, cancer remains a major cause of death in children, with the survivors developing anticancer treatment-specific health problems. Therefore, the anticancer treatment needs further improvement. Melatonin is a effective antioxidant and circadian pacemaker. Through multiple mechanisms, melatonin has significant positive effects on multitude adult cancers by increasing survival and treatment response rates, and slowing disease progression. In addition, melatonin appears to be safe for children. As an appealing therapeutic agent, we herein address several key concerns regarding melatonin's potential for treating children with cancer.",

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AU - Chao, Yu Hua

AU - Wu, Kang Hsi

AU - Yeh, Chia Ming

AU - Su, Shih Chi

AU - Reiter, Russel J.

AU - Yang, Shun Fa

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N2 - Childhood cancer management has improved considerably, with the overall objective of preventing early-life cancers completely. However, cancer remains a major cause of death in children, with the survivors developing anticancer treatment-specific health problems. Therefore, the anticancer treatment needs further improvement. Melatonin is a effective antioxidant and circadian pacemaker. Through multiple mechanisms, melatonin has significant positive effects on multitude adult cancers by increasing survival and treatment response rates, and slowing disease progression. In addition, melatonin appears to be safe for children. As an appealing therapeutic agent, we herein address several key concerns regarding melatonin's potential for treating children with cancer.

AB - Childhood cancer management has improved considerably, with the overall objective of preventing early-life cancers completely. However, cancer remains a major cause of death in children, with the survivors developing anticancer treatment-specific health problems. Therefore, the anticancer treatment needs further improvement. Melatonin is a effective antioxidant and circadian pacemaker. Through multiple mechanisms, melatonin has significant positive effects on multitude adult cancers by increasing survival and treatment response rates, and slowing disease progression. In addition, melatonin appears to be safe for children. As an appealing therapeutic agent, we herein address several key concerns regarding melatonin's potential for treating children with cancer.

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The potential utility of melatonin in the treatment of childhood cancer

Abstract

Keywords

ASJC Scopus subject areas

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