TY - JOUR
T1 - The potential of hydroxyapatite toothpaste to prevent root caries
T2 - A pH-cycling study
AU - Amaechi, Bennett Tochukwu
AU - Phillips, Thais Santiago
AU - Evans, Veronica
AU - Ugwokaegbe, Chidera Precious
AU - Luong, Minh Nguyet
AU - Okoye, Linda Oge
AU - Meyer, Frederic
AU - Enax, Joachim
N1 - Publisher Copyright:
© 2021 Amaechi et al.
PY - 2021
Y1 - 2021
N2 - Purpose The effectiveness of a hydroxyapatite (HAP) toothpaste and a fluoride toothpaste in preventing root tissue demineralization (root caries) was compared using an established pH-cycling caries model. Materials and Methods Sixty dentin blocks were produced from the root tissue of extracted human teeth and were assigned to 3 test groups (n=20/group): 10% hydroxyapatite toothpaste (HAP), 1450 ppm fluoride toothpaste (fluoride), and artificial saliva (artsaliva). Early root caries lesions were developed in each sample by 7-day demineralization using a pH-cycling caries model. The daily cyclic treatment regimen consists of two 2-minute toothpaste-slurry treatment periods, one 6-hour acid challenge using acidified gel (pH 4.5), and then storage in remineralizing solution (artsaliva) for the rest of the time. Demineralization was assessed as the amount of mineral loss (∆z) using transverse microradiography (TMR). Pairwise comparisons (between treatments) were performed using analysis of variance (ANOVA), and then Tukey’s HSD for multiple comparisons. All p-values are considered significant if p<0.05. Results Both ANOVA and Tukey’s HSD indicated no significant (ANOVA; n=20) difference in mean ∆z among the groups, with least ∆z (±Sd) in the HAP (1117±366) compared to fluoride (1392±334) and artsaliva (1406±223). Relative to control, HAP and fluoride inhibited root demineralization by 21% and 6%, respectively. Conclusion Within the limit of the present study, the tested toothpaste containing 10% HAP is an effective root caries control toothpaste. Toothpaste containing 10% HAP was slightly more effective in preventing tooth demineralization than 1450 ppm fluoride provided as sodium fluoride. Thus, this study shows that HAP toothpastes can serve as an effective alternative to fluoride toothpastes for root caries management.
AB - Purpose The effectiveness of a hydroxyapatite (HAP) toothpaste and a fluoride toothpaste in preventing root tissue demineralization (root caries) was compared using an established pH-cycling caries model. Materials and Methods Sixty dentin blocks were produced from the root tissue of extracted human teeth and were assigned to 3 test groups (n=20/group): 10% hydroxyapatite toothpaste (HAP), 1450 ppm fluoride toothpaste (fluoride), and artificial saliva (artsaliva). Early root caries lesions were developed in each sample by 7-day demineralization using a pH-cycling caries model. The daily cyclic treatment regimen consists of two 2-minute toothpaste-slurry treatment periods, one 6-hour acid challenge using acidified gel (pH 4.5), and then storage in remineralizing solution (artsaliva) for the rest of the time. Demineralization was assessed as the amount of mineral loss (∆z) using transverse microradiography (TMR). Pairwise comparisons (between treatments) were performed using analysis of variance (ANOVA), and then Tukey’s HSD for multiple comparisons. All p-values are considered significant if p<0.05. Results Both ANOVA and Tukey’s HSD indicated no significant (ANOVA; n=20) difference in mean ∆z among the groups, with least ∆z (±Sd) in the HAP (1117±366) compared to fluoride (1392±334) and artsaliva (1406±223). Relative to control, HAP and fluoride inhibited root demineralization by 21% and 6%, respectively. Conclusion Within the limit of the present study, the tested toothpaste containing 10% HAP is an effective root caries control toothpaste. Toothpaste containing 10% HAP was slightly more effective in preventing tooth demineralization than 1450 ppm fluoride provided as sodium fluoride. Thus, this study shows that HAP toothpastes can serve as an effective alternative to fluoride toothpastes for root caries management.
KW - Artificial saliva
KW - Demineralization
KW - Fluoride
KW - Hydroxyapatite
KW - PH cycling
KW - Toothpaste
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U2 - 10.2147/CCIDE.S319631
DO - 10.2147/CCIDE.S319631
M3 - Article
C2 - 34321930
AN - SCOPUS:85112007644
SN - 1179-1357
VL - 13
SP - 315
EP - 324
JO - Clinical, Cosmetic and Investigational Dentistry
JF - Clinical, Cosmetic and Investigational Dentistry
ER -