The portal hypertensive effect of dopamine

Carl E. Tetirick; Neil R. Thomford; William G. Pace; Kenneth R. Sirinek

doi:10.1016/0022-4804(77)90108-1

The portal hypertensive effect of dopamine

Carl E. Tetirick, Neil R. Thomford, William G. Pace, Kenneth R. Sirinek

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Intravenous infusions of either dopamine, vasopressin, or simultaneous dopamine and vasopressin were administered to normal adult mongrel dogs, and the effect on systemic and portal hemodynamics monitored. Dopamine increased superior mesenteric artery blood flow and portal venous pressure. Because of this portal hypertensive effect, dopamine should not be given to patients with cirrhosis and portal hypertension. Dopamine administered with vasopressin failed to protect against a reduction in cardiac output, and completely reversed the portal hypotensive effect of vasopressin. Isoproterenol remains the drug of choice for offsetting the adverse hemodynamic effects of vasopressin administration.

Original language	English (US)
Pages (from-to)	671-678
Number of pages	8
Journal	Journal of Surgical Research
Volume	22
Issue number	6
DOIs	https://doi.org/10.1016/0022-4804(77)90108-1
State	Published - Jun 1977
Externally published	Yes

ASJC Scopus subject areas

Surgery

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10.1016/0022-4804(77)90108-1

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title = "The portal hypertensive effect of dopamine",

abstract = "Intravenous infusions of either dopamine, vasopressin, or simultaneous dopamine and vasopressin were administered to normal adult mongrel dogs, and the effect on systemic and portal hemodynamics monitored. Dopamine increased superior mesenteric artery blood flow and portal venous pressure. Because of this portal hypertensive effect, dopamine should not be given to patients with cirrhosis and portal hypertension. Dopamine administered with vasopressin failed to protect against a reduction in cardiac output, and completely reversed the portal hypotensive effect of vasopressin. Isoproterenol remains the drug of choice for offsetting the adverse hemodynamic effects of vasopressin administration.",

author = "Tetirick, {Carl E.} and Thomford, {Neil R.} and Pace, {William G.} and Sirinek, {Kenneth R.}",

note = "Funding Information: I Supported by a grant from The John A. Hartford Foundation, Inc. Technical assistance was supplied by Mr. George Funakoshi and Mr. William Yorde. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1977",

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doi = "10.1016/0022-4804(77)90108-1",

language = "English (US)",

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T1 - The portal hypertensive effect of dopamine

AU - Tetirick, Carl E.

AU - Thomford, Neil R.

AU - Pace, William G.

AU - Sirinek, Kenneth R.

N1 - Funding Information: I Supported by a grant from The John A. Hartford Foundation, Inc. Technical assistance was supplied by Mr. George Funakoshi and Mr. William Yorde. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1977/6

Y1 - 1977/6

N2 - Intravenous infusions of either dopamine, vasopressin, or simultaneous dopamine and vasopressin were administered to normal adult mongrel dogs, and the effect on systemic and portal hemodynamics monitored. Dopamine increased superior mesenteric artery blood flow and portal venous pressure. Because of this portal hypertensive effect, dopamine should not be given to patients with cirrhosis and portal hypertension. Dopamine administered with vasopressin failed to protect against a reduction in cardiac output, and completely reversed the portal hypotensive effect of vasopressin. Isoproterenol remains the drug of choice for offsetting the adverse hemodynamic effects of vasopressin administration.

AB - Intravenous infusions of either dopamine, vasopressin, or simultaneous dopamine and vasopressin were administered to normal adult mongrel dogs, and the effect on systemic and portal hemodynamics monitored. Dopamine increased superior mesenteric artery blood flow and portal venous pressure. Because of this portal hypertensive effect, dopamine should not be given to patients with cirrhosis and portal hypertension. Dopamine administered with vasopressin failed to protect against a reduction in cardiac output, and completely reversed the portal hypotensive effect of vasopressin. Isoproterenol remains the drug of choice for offsetting the adverse hemodynamic effects of vasopressin administration.

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The portal hypertensive effect of dopamine

Abstract

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