The place of GLP-1-based therapy in diabetes management: Differences between DPP-4 inhibitors and GLP-1 receptor agonists

Dara L. Eckerle Mize; Marzieh Salehi

doi:10.1007/s11892-013-0377-9

The place of GLP-1-based therapy in diabetes management: Differences between DPP-4 inhibitors and GLP-1 receptor agonists

Dara L. Eckerle Mize, Marzieh Salehi

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Type 2 diabetes is a progressive disease characterized by the need for additional antidiabetic agents overtime to maintain a stable level of glycemic control. The discovery of the glucagon like peptide 1, 1 of the 2 major incretins, was pivotal to the development of novel therapies, which can be used in individuals with type 2 diabetes. Two classes of drugs, GLP-1 receptor agonists and dipeptidyl peptidase inhibitors, provide comparable or superior glycemic effects to previous antidiabetic agents without increasing side effects, such as weight gain and hypoglycemia. Therefore, they represent valuable additions to the current therapeutic options for type 2 diabetes.

Original language	English (US)
Pages (from-to)	307-318
Number of pages	12
Journal	Current Diabetes Reports
Volume	13
Issue number	3
DOIs	https://doi.org/10.1007/s11892-013-0377-9
State	Published - Jun 2013
Externally published	Yes

Keywords

Cardiovascular risk factors
DPP-4
DPP-4 inhibitors
GLP-1
GLP-1 receptor agonists
Hypoglycemia
Incretin
Type 2 diabetes
Weight loss

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism

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abstract = "Type 2 diabetes is a progressive disease characterized by the need for additional antidiabetic agents overtime to maintain a stable level of glycemic control. The discovery of the glucagon like peptide 1, 1 of the 2 major incretins, was pivotal to the development of novel therapies, which can be used in individuals with type 2 diabetes. Two classes of drugs, GLP-1 receptor agonists and dipeptidyl peptidase inhibitors, provide comparable or superior glycemic effects to previous antidiabetic agents without increasing side effects, such as weight gain and hypoglycemia. Therefore, they represent valuable additions to the current therapeutic options for type 2 diabetes.",

keywords = "Cardiovascular risk factors, DPP-4, DPP-4 inhibitors, GLP-1, GLP-1 receptor agonists, Hypoglycemia, Incretin, Type 2 diabetes, Weight loss",

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note = "Funding Information: Acknowledgement Marzieh Salehi has received an NIH grant (DK083554).",

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AU - Salehi, Marzieh

N1 - Funding Information: Acknowledgement Marzieh Salehi has received an NIH grant (DK083554).

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The place of GLP-1-based therapy in diabetes management: Differences between DPP-4 inhibitors and GLP-1 receptor agonists

Abstract

Keywords

ASJC Scopus subject areas

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