The pineal hormone melatonin inhibits DNA-adduct formation induced by the chemical carcinogen safrole in vivo

Dun Xian Tan; Burkhard Pöeggeler; Russel J. Reiter; Li Dun Chen; Shou Chen; Manchester C. Lucien; Lornell R. Barlow-Walden

doi:10.1016/0304-3835(93)90076-L

The pineal hormone melatonin inhibits DNA-adduct formation induced by the chemical carcinogen safrole in vivo

Dun Xian Tan, Burkhard Pöeggeler, Russel J. Reiter, Li Dun Chen, Shou Chen, Manchester C. Lucien, Lornell R. Barlow-Walden

Research output: Contribution to journal › Article › peer-review

305 Scopus citations

Abstract

Melatonin inhibits DNA-adduct formation induced by the chemical carcinogen safrole in a dose-dependent manner. Total DNA-adduct formation after in vivo administration of 300 mg/kg safrole measured by ³²P-postlabeling analysis of carcinogen-modified DNA in rat liver was 36 751 ± 2290 counts/min/10 μg DNA. Coad-ministration of 300 mg/kg safrole with either 0.2 mg/kg (low dose) or 0.4 mg/kg (high dose) melatonin reduced DNA-adduct formation induced by safrole to 22 182 ± 987 counts/min/10 μg DNA and 462 ± 283 counts/min/10 μg DNA, respectively. Circulating melatonin concentrations at the termination of the study in safrole, low melatonin and high melatonin groups were 50 ± 8, 3140 ± 430 and 10 040 ± 2610 pg/ml serum, respectively. The results suggest that melatonin protects against safrole associated DNA damage.

Original language	English (US)
Pages (from-to)	65-71
Number of pages	7
Journal	Cancer Letters
Volume	70
Issue number	1-2
DOIs	https://doi.org/10.1016/0304-3835(93)90076-L
State	Published - Jun 15 1993

Keywords

DNA adduct
carcinogen
melatonin
safrole

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/0304-3835(93)90076-L

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title = "The pineal hormone melatonin inhibits DNA-adduct formation induced by the chemical carcinogen safrole in vivo",

abstract = "Melatonin inhibits DNA-adduct formation induced by the chemical carcinogen safrole in a dose-dependent manner. Total DNA-adduct formation after in vivo administration of 300 mg/kg safrole measured by 32P-postlabeling analysis of carcinogen-modified DNA in rat liver was 36 751 ± 2290 counts/min/10 μg DNA. Coad-ministration of 300 mg/kg safrole with either 0.2 mg/kg (low dose) or 0.4 mg/kg (high dose) melatonin reduced DNA-adduct formation induced by safrole to 22 182 ± 987 counts/min/10 μg DNA and 462 ± 283 counts/min/10 μg DNA, respectively. Circulating melatonin concentrations at the termination of the study in safrole, low melatonin and high melatonin groups were 50 ± 8, 3140 ± 430 and 10 040 ± 2610 pg/ml serum, respectively. The results suggest that melatonin protects against safrole associated DNA damage.",

keywords = "DNA adduct, carcinogen, melatonin, safrole",

author = "Tan, {Dun Xian} and Burkhard P{\"o}eggeler and Reiter, {Russel J.} and Chen, {Li Dun} and Shou Chen and Lucien, {Manchester C.} and Barlow-Walden, {Lornell R.}",

note = "Funding Information: This work was supportedb y NSF IBN 9121262to RJR.",

year = "1993",

month = jun,

day = "15",

doi = "10.1016/0304-3835(93)90076-L",

language = "English (US)",

volume = "70",

pages = "65--71",

journal = "Cancer Letters",

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T1 - The pineal hormone melatonin inhibits DNA-adduct formation induced by the chemical carcinogen safrole in vivo

AU - Tan, Dun Xian

AU - Pöeggeler, Burkhard

AU - Reiter, Russel J.

AU - Chen, Li Dun

AU - Chen, Shou

AU - Lucien, Manchester C.

AU - Barlow-Walden, Lornell R.

N1 - Funding Information: This work was supportedb y NSF IBN 9121262to RJR.

PY - 1993/6/15

Y1 - 1993/6/15

N2 - Melatonin inhibits DNA-adduct formation induced by the chemical carcinogen safrole in a dose-dependent manner. Total DNA-adduct formation after in vivo administration of 300 mg/kg safrole measured by 32P-postlabeling analysis of carcinogen-modified DNA in rat liver was 36 751 ± 2290 counts/min/10 μg DNA. Coad-ministration of 300 mg/kg safrole with either 0.2 mg/kg (low dose) or 0.4 mg/kg (high dose) melatonin reduced DNA-adduct formation induced by safrole to 22 182 ± 987 counts/min/10 μg DNA and 462 ± 283 counts/min/10 μg DNA, respectively. Circulating melatonin concentrations at the termination of the study in safrole, low melatonin and high melatonin groups were 50 ± 8, 3140 ± 430 and 10 040 ± 2610 pg/ml serum, respectively. The results suggest that melatonin protects against safrole associated DNA damage.

AB - Melatonin inhibits DNA-adduct formation induced by the chemical carcinogen safrole in a dose-dependent manner. Total DNA-adduct formation after in vivo administration of 300 mg/kg safrole measured by 32P-postlabeling analysis of carcinogen-modified DNA in rat liver was 36 751 ± 2290 counts/min/10 μg DNA. Coad-ministration of 300 mg/kg safrole with either 0.2 mg/kg (low dose) or 0.4 mg/kg (high dose) melatonin reduced DNA-adduct formation induced by safrole to 22 182 ± 987 counts/min/10 μg DNA and 462 ± 283 counts/min/10 μg DNA, respectively. Circulating melatonin concentrations at the termination of the study in safrole, low melatonin and high melatonin groups were 50 ± 8, 3140 ± 430 and 10 040 ± 2610 pg/ml serum, respectively. The results suggest that melatonin protects against safrole associated DNA damage.

KW - DNA adduct

KW - carcinogen

KW - melatonin

KW - safrole

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The pineal hormone melatonin inhibits DNA-adduct formation induced by the chemical carcinogen safrole in vivo

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