The pineal hormone melatonin inhibits DNA-adduct formation induced by the chemical carcinogen safrole in vivo

Dun Xian Tan, Burkhard Pöeggeler, Russel J. Reiter, Li Dun Chen, Shou Chen, Manchester C. Lucien, Lornell R. Barlow-Walden

Research output: Contribution to journalArticlepeer-review

287 Scopus citations

Abstract

Melatonin inhibits DNA-adduct formation induced by the chemical carcinogen safrole in a dose-dependent manner. Total DNA-adduct formation after in vivo administration of 300 mg/kg safrole measured by 32P-postlabeling analysis of carcinogen-modified DNA in rat liver was 36 751 ± 2290 counts/min/10 μg DNA. Coad-ministration of 300 mg/kg safrole with either 0.2 mg/kg (low dose) or 0.4 mg/kg (high dose) melatonin reduced DNA-adduct formation induced by safrole to 22 182 ± 987 counts/min/10 μg DNA and 462 ± 283 counts/min/10 μg DNA, respectively. Circulating melatonin concentrations at the termination of the study in safrole, low melatonin and high melatonin groups were 50 ± 8, 3140 ± 430 and 10 040 ± 2610 pg/ml serum, respectively. The results suggest that melatonin protects against safrole associated DNA damage.

Original languageEnglish (US)
Pages (from-to)65-71
Number of pages7
JournalCancer Letters
Volume70
Issue number1-2
DOIs
StatePublished - Jun 15 1993

Keywords

  • DNA adduct
  • carcinogen
  • melatonin
  • safrole

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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