The pineal hormone melatonin inhibits DNA-adduct formation induced by the chemical carcinogen safrole in vivo

Dun Xian Tan, Burkhard Pöeggeler, Russel J Reiter, Li Dun Chen, Shuo Chen, Manchester C. Lucien, Lornell R. Barlow-Walden

Research output: Contribution to journalArticle

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Abstract

Melatonin inhibits DNA-adduct formation induced by the chemical carcinogen safrole in a dose-dependent manner. Total DNA-adduct formation after in vivo administration of 300 mg/kg safrole measured by 32P-postlabeling analysis of carcinogen-modified DNA in rat liver was 36 751 ± 2290 counts/min/10 μg DNA. Coad-ministration of 300 mg/kg safrole with either 0.2 mg/kg (low dose) or 0.4 mg/kg (high dose) melatonin reduced DNA-adduct formation induced by safrole to 22 182 ± 987 counts/min/10 μg DNA and 462 ± 283 counts/min/10 μg DNA, respectively. Circulating melatonin concentrations at the termination of the study in safrole, low melatonin and high melatonin groups were 50 ± 8, 3140 ± 430 and 10 040 ± 2610 pg/ml serum, respectively. The results suggest that melatonin protects against safrole associated DNA damage.

Original languageEnglish (US)
Pages (from-to)65-71
Number of pages7
JournalCancer Letters
Volume70
Issue number1-2
DOIs
StatePublished - Jun 15 1993

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Safrole
DNA Adducts
Melatonin
Carcinogens
Hormones
DNA
DNA Damage
Liver
Serum

Keywords

  • carcinogen
  • DNA adduct
  • melatonin
  • safrole

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

The pineal hormone melatonin inhibits DNA-adduct formation induced by the chemical carcinogen safrole in vivo. / Tan, Dun Xian; Pöeggeler, Burkhard; Reiter, Russel J; Chen, Li Dun; Chen, Shuo; Lucien, Manchester C.; Barlow-Walden, Lornell R.

In: Cancer Letters, Vol. 70, No. 1-2, 15.06.1993, p. 65-71.

Research output: Contribution to journalArticle

Tan, Dun Xian ; Pöeggeler, Burkhard ; Reiter, Russel J ; Chen, Li Dun ; Chen, Shuo ; Lucien, Manchester C. ; Barlow-Walden, Lornell R. / The pineal hormone melatonin inhibits DNA-adduct formation induced by the chemical carcinogen safrole in vivo. In: Cancer Letters. 1993 ; Vol. 70, No. 1-2. pp. 65-71.
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