The Physiology of Early Goal-Directed Therapy for Sepsis

Lindsay Lief, John Arbo, David A. Berlin

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


In 2001, Rivers and colleagues published a randomized controlled trial of early goal-directed therapy (EGDT) for the treatment of sepsis. More than a decade later, it remains a landmark achievement. The study proved the benefits of early aggressive treatment of sepsis. However, many questions remain about specific aspects of the complex EGDT algorithm. Recently, 3 large trials attempted to replicate these results. None of the studies demonstrated a benefit of an EGDT protocol for sepsis. This review explores the physiologic basis of goal-directed therapy, including the hemodynamic targets and the therapeutic interventions. An understanding of the physiologic basis of EGDT helps reconcile the results of the clinical trials.

Original languageEnglish (US)
Pages (from-to)567-573
Number of pages7
JournalJournal of Intensive Care Medicine
Issue number10
StatePublished - Dec 1 2017
Externally publishedYes


  • goal-directed therapy
  • oxygen consumption
  • oxygen delivery
  • sepsis
  • venous oxygen saturation

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


Dive into the research topics of 'The Physiology of Early Goal-Directed Therapy for Sepsis'. Together they form a unique fingerprint.

Cite this