Abstract
The worldwide incidence of striated muscle diseases, including cardiomyopathies and skeletal muscle impairments, is greater than 30% of the population. These categories of diseases have many differences and also multiple similarities; also, what affects one muscle type is often associated with damage to the other as well. Treatment is usually focused on one without addressing the other tissue involved in the disease process; this may make overall treatment less effective. It is important to consider these diseases globally with the intent of improving skeletal and cardiac muscle physiology simultaneously. Melatonin, due to its unrivaled antioxidant and anti-inflammatory capabilities, increases muscle satellite cells, improves mitochondrial quality and reduces calcium overload in striated muscle. These actions may make melatonin a viable therapeutic option to satisfactorily not only treat, but also prevent, damage in cardiac as well as skeletal muscle. This review summarizes data from recent published literature that documents the unparalleled potential of melatonin as a useful agent against both skeletal and cardiac muscle diseases.
| Original language | English (US) |
|---|---|
| Title of host publication | Pineal Gland |
| Subtitle of host publication | Research Advances and Clinical Challenges |
| Publisher | Nova Science Publishers, Inc. |
| Pages | 1-38 |
| Number of pages | 38 |
| ISBN (Electronic) | 9781536121476 |
| ISBN (Print) | 9781536121179 |
| State | Published - Sep 29 2017 |
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Keywords
- Atrophy
- Cardiac muscle
- Cardiomyopathy
- Dystrophy
- Heart
- Heart failure
- Melatonin
- Myocyte
- Skeletal muscle
- Striated muscle
ASJC Scopus subject areas
- Medicine(all)
Cite this
The physiology and pathology of skeletal and cardiac muscle : Beneficial actions of melatonin. / Coto-Montes, Ana; Boga, José A.; Tan, Dun X.; Reiter, Russel J.
Pineal Gland: Research Advances and Clinical Challenges. Nova Science Publishers, Inc., 2017. p. 1-38.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - The physiology and pathology of skeletal and cardiac muscle
T2 - Beneficial actions of melatonin
AU - Coto-Montes, Ana
AU - Boga, José A.
AU - Tan, Dun X.
AU - Reiter, Russel J
PY - 2017/9/29
Y1 - 2017/9/29
N2 - The worldwide incidence of striated muscle diseases, including cardiomyopathies and skeletal muscle impairments, is greater than 30% of the population. These categories of diseases have many differences and also multiple similarities; also, what affects one muscle type is often associated with damage to the other as well. Treatment is usually focused on one without addressing the other tissue involved in the disease process; this may make overall treatment less effective. It is important to consider these diseases globally with the intent of improving skeletal and cardiac muscle physiology simultaneously. Melatonin, due to its unrivaled antioxidant and anti-inflammatory capabilities, increases muscle satellite cells, improves mitochondrial quality and reduces calcium overload in striated muscle. These actions may make melatonin a viable therapeutic option to satisfactorily not only treat, but also prevent, damage in cardiac as well as skeletal muscle. This review summarizes data from recent published literature that documents the unparalleled potential of melatonin as a useful agent against both skeletal and cardiac muscle diseases.
AB - The worldwide incidence of striated muscle diseases, including cardiomyopathies and skeletal muscle impairments, is greater than 30% of the population. These categories of diseases have many differences and also multiple similarities; also, what affects one muscle type is often associated with damage to the other as well. Treatment is usually focused on one without addressing the other tissue involved in the disease process; this may make overall treatment less effective. It is important to consider these diseases globally with the intent of improving skeletal and cardiac muscle physiology simultaneously. Melatonin, due to its unrivaled antioxidant and anti-inflammatory capabilities, increases muscle satellite cells, improves mitochondrial quality and reduces calcium overload in striated muscle. These actions may make melatonin a viable therapeutic option to satisfactorily not only treat, but also prevent, damage in cardiac as well as skeletal muscle. This review summarizes data from recent published literature that documents the unparalleled potential of melatonin as a useful agent against both skeletal and cardiac muscle diseases.
KW - Atrophy
KW - Cardiac muscle
KW - Cardiomyopathy
KW - Dystrophy
KW - Heart
KW - Heart failure
KW - Melatonin
KW - Myocyte
KW - Skeletal muscle
KW - Striated muscle
UR - http://www.scopus.com/inward/record.url?scp=85058194221&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85058194221&partnerID=8YFLogxK
M3 - Chapter
SN - 9781536121179
SP - 1
EP - 38
BT - Pineal Gland
PB - Nova Science Publishers, Inc.
ER -