The pharmacokinetics of teicoplanin in varying degrees of renal function

Y. W.Francis Lam, Joan E. Kapusnik‐Uner, Meena Sachdeva, Corinne Hackbarth, John G. Gambertoglio, Merle A. Sande

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

The pharmacokinetics of teicoplanin, a new glycopeptide antibiotic with activity against aerobic gram‐positive bacteria, were characterized after intravenous administration of a single 3 mg/kg dose in five healthy volunteers and six patients with various degrees of stable renal insufficiency. Serum and urine samples were collected during a 15‐day period and drug concentrations were assayed microbiologically. The mean elimination half‐life of teicoplanin was 162.6 ± 69.8 hours in healthy volunteers and was prolonged with decreased renal function. The mean plasma and renal clearances of teicoplanin in healthy subjects were 11.4 ± 1.5 ml/min and 10.0 ± 1.0 ml/min, respectively. Both values decreased in patients with renal failure and correlated significantly with measured creatinine clearances (r2 = 0.938 and 0.884, respectively). A nomogram for dosage adjustment in patients with varying degrees of renal failure is presented. Clinical Pharmacology and Therapeutics (1990) 47, 655–661; doi:

Original languageEnglish (US)
Pages (from-to)655-661
Number of pages7
JournalClinical Pharmacology & Therapeutics
Volume47
Issue number5
DOIs
StatePublished - May 1990

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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