Abstract
Thirty patients at term undergoing cesarean section received intraoperative irrigation with either cefamandole, cephalothin, or ampicillin to prevent postoperative infection. Serum drug levels were measured at 15, 60 and 120 minutes after completion of irrigation. Serum levels at each sampling interval were highest for cefamandole and lowest for cephalothin. Less than 2% of the total drug dose was excreted in the urine during the first 2 postoperative hours. In most patients, maximum serum antibiotic concentrations exceeded minimal inhibitory concentrations for several recognized pelvic pathogens. It is concluded that the mechanism of action of intraoperative irrigation may in part be due to systemic absorption of antibiotic and not simply to a local effect on the endometrium. Moreover, the degree of systemic absorption may be sufficient to cause allergic drug reactions and to exert selective pressures for the emergence of drug-resistant microorganisms.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 409-412 |
| Number of pages | 4 |
| Journal | Obstetrics and Gynecology |
| Volume | 60 |
| Issue number | 4 |
| State | Published - 1982 |
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ASJC Scopus subject areas
- Obstetrics and Gynecology
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The pharmacokinetics of prophylactic antibiotics administered by intraoperative irrigation at the time of cesarean section. / Duff, P.; Gibbs, R. S.; Jorgensen, J. H.; Alexander, G.
In: Obstetrics and Gynecology, Vol. 60, No. 4, 1982, p. 409-412.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The pharmacokinetics of prophylactic antibiotics administered by intraoperative irrigation at the time of cesarean section
AU - Duff, P.
AU - Gibbs, R. S.
AU - Jorgensen, J. H.
AU - Alexander, G.
PY - 1982
Y1 - 1982
N2 - Thirty patients at term undergoing cesarean section received intraoperative irrigation with either cefamandole, cephalothin, or ampicillin to prevent postoperative infection. Serum drug levels were measured at 15, 60 and 120 minutes after completion of irrigation. Serum levels at each sampling interval were highest for cefamandole and lowest for cephalothin. Less than 2% of the total drug dose was excreted in the urine during the first 2 postoperative hours. In most patients, maximum serum antibiotic concentrations exceeded minimal inhibitory concentrations for several recognized pelvic pathogens. It is concluded that the mechanism of action of intraoperative irrigation may in part be due to systemic absorption of antibiotic and not simply to a local effect on the endometrium. Moreover, the degree of systemic absorption may be sufficient to cause allergic drug reactions and to exert selective pressures for the emergence of drug-resistant microorganisms.
AB - Thirty patients at term undergoing cesarean section received intraoperative irrigation with either cefamandole, cephalothin, or ampicillin to prevent postoperative infection. Serum drug levels were measured at 15, 60 and 120 minutes after completion of irrigation. Serum levels at each sampling interval were highest for cefamandole and lowest for cephalothin. Less than 2% of the total drug dose was excreted in the urine during the first 2 postoperative hours. In most patients, maximum serum antibiotic concentrations exceeded minimal inhibitory concentrations for several recognized pelvic pathogens. It is concluded that the mechanism of action of intraoperative irrigation may in part be due to systemic absorption of antibiotic and not simply to a local effect on the endometrium. Moreover, the degree of systemic absorption may be sufficient to cause allergic drug reactions and to exert selective pressures for the emergence of drug-resistant microorganisms.
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UR - http://www.scopus.com/inward/citedby.url?scp=0019941996&partnerID=8YFLogxK
M3 - Article
C2 - 7121925
AN - SCOPUS:0019941996
VL - 60
SP - 409
EP - 412
JO - Obstetrics and Gynecology
JF - Obstetrics and Gynecology
SN - 0029-7844
IS - 4
ER -