The perspective of GABA replenishment therapy in the epilepsies: A critical evaluation of hopes and concerns

Ruggero G. Fariello, Maharaj K. Ticku

Research output: Contribution to journalShort surveypeer-review

44 Scopus citations

Abstract

Impaired GABA-mediated inhibition is probably one of the cellular abnormalities leading to Focal Epilepsy. The role of GABA in generalized seizures, particularly of Petit Mal type, is unknown. Various approaches are available to potentiate GABA function. Merits and flaws of each one of them are critically evaluated. In some forms of epilepsy, GABA agonists may replenish depleted pools, and in some others may nonspecifically raise the general excitability threshold of the brain, yet in other forms they may exert a glutamate/aspartate antagonistic effect. The available experimental evidence suggests that in bilaterally synchronous spike and wave epilepsies, GABA agonists are either ineffective or pejorative.

Original languageEnglish (US)
Pages (from-to)1629-1640
Number of pages12
JournalLife Sciences
Volume33
Issue number17
DOIs
StatePublished - Oct 24 1983

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Fingerprint

Dive into the research topics of 'The perspective of GABA replenishment therapy in the epilepsies: A critical evaluation of hopes and concerns'. Together they form a unique fingerprint.

Cite this