The PELP1 Pathway and Its Importance in Cancer Treatment

Khaled Mohamed Nassar; Panneerdoss Subbarayalu; Suryavathi Viswanadhapalli; Ratna K. Vadlamudi

doi:10.3390/biom15121729

The PELP1 Pathway and Its Importance in Cancer Treatment

Research output: Contribution to journal › Review article › peer-review

Abstract

Proline-, glutamic acid-, and leucine-rich protein 1 (PELP1) is a proto-oncogene that serves as a nuclear and cytoplasmic scaffolding protein. PELP1 plays a critical role in nuclear receptor signaling, ribosome biogenesis, chromatin modifications, cell cycle progression, non-genomic signaling, and DNA damage response. PELP1 expression is upregulated in a variety of cancers, including breast, ovarian, endometrial, prostate, and liver cancers and serves as a prognostic factor for poor survival. PELP1’s structural motifs, unique scaffolding function, and oncogenic activity make it a potential target for a range of therapeutic approaches. This review summarizes the most recent advancements in PELP1 biology, with a particular focus on the emergent oncogenic functions of PELP1 and its inhibitors for the treatment of cancer.

Original language	English (US)
Article number	1729
Journal	Biomolecules
Volume	15
Issue number	12
DOIs	https://doi.org/10.3390/biom15121729
State	Published - Dec 2025

Keywords

PELP1
PELP1 inhibitors
Rix complex
oncogene

ASJC Scopus subject areas

Biochemistry
Molecular Biology

Access to Document

10.3390/biom15121729

Cite this

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title = "The PELP1 Pathway and Its Importance in Cancer Treatment",

abstract = "Proline-, glutamic acid-, and leucine-rich protein 1 (PELP1) is a proto-oncogene that serves as a nuclear and cytoplasmic scaffolding protein. PELP1 plays a critical role in nuclear receptor signaling, ribosome biogenesis, chromatin modifications, cell cycle progression, non-genomic signaling, and DNA damage response. PELP1 expression is upregulated in a variety of cancers, including breast, ovarian, endometrial, prostate, and liver cancers and serves as a prognostic factor for poor survival. PELP1{\textquoteright}s structural motifs, unique scaffolding function, and oncogenic activity make it a potential target for a range of therapeutic approaches. This review summarizes the most recent advancements in PELP1 biology, with a particular focus on the emergent oncogenic functions of PELP1 and its inhibitors for the treatment of cancer.",

keywords = "PELP1, PELP1 inhibitors, Rix complex, oncogene",

author = "Nassar, \{Khaled Mohamed\} and Panneerdoss Subbarayalu and Suryavathi Viswanadhapalli and Vadlamudi, \{Ratna K.\}",

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doi = "10.3390/biom15121729",

language = "English (US)",

volume = "15",

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AU - Nassar, Khaled Mohamed

AU - Subbarayalu, Panneerdoss

AU - Viswanadhapalli, Suryavathi

AU - Vadlamudi, Ratna K.

PY - 2025/12

Y1 - 2025/12

N2 - Proline-, glutamic acid-, and leucine-rich protein 1 (PELP1) is a proto-oncogene that serves as a nuclear and cytoplasmic scaffolding protein. PELP1 plays a critical role in nuclear receptor signaling, ribosome biogenesis, chromatin modifications, cell cycle progression, non-genomic signaling, and DNA damage response. PELP1 expression is upregulated in a variety of cancers, including breast, ovarian, endometrial, prostate, and liver cancers and serves as a prognostic factor for poor survival. PELP1’s structural motifs, unique scaffolding function, and oncogenic activity make it a potential target for a range of therapeutic approaches. This review summarizes the most recent advancements in PELP1 biology, with a particular focus on the emergent oncogenic functions of PELP1 and its inhibitors for the treatment of cancer.

AB - Proline-, glutamic acid-, and leucine-rich protein 1 (PELP1) is a proto-oncogene that serves as a nuclear and cytoplasmic scaffolding protein. PELP1 plays a critical role in nuclear receptor signaling, ribosome biogenesis, chromatin modifications, cell cycle progression, non-genomic signaling, and DNA damage response. PELP1 expression is upregulated in a variety of cancers, including breast, ovarian, endometrial, prostate, and liver cancers and serves as a prognostic factor for poor survival. PELP1’s structural motifs, unique scaffolding function, and oncogenic activity make it a potential target for a range of therapeutic approaches. This review summarizes the most recent advancements in PELP1 biology, with a particular focus on the emergent oncogenic functions of PELP1 and its inhibitors for the treatment of cancer.

KW - PELP1

KW - PELP1 inhibitors

KW - Rix complex

KW - oncogene

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UR - https://www.scopus.com/pages/publications/105025717934#tab=citedBy

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The PELP1 Pathway and Its Importance in Cancer Treatment

Abstract

Keywords

ASJC Scopus subject areas

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