The pediatric solid organ transplant experience with COVID-19: An initial multi-center, multi-organ case series

Matthew B. Goss, N. Thao N. Galván, Wenly Ruan, Flor M. Munoz, Eileen D. Brewer, Christine A. O’Mahony, Ernestina Melicoff-Portillo, William J. Dreyer, Tamir A. Miloh, Francisco G. Cigarroa, Daniel Ranch, Dor Yoeli, Megan A. Adams, Sarah Koohmaraie, Diana M. Harter, Abbas Rana, Ronald T. Cotton, Beth Carter, Shreena Patel, Nicolas F. MorenoDaniel H. Leung, John A. Goss

Research output: Contribution to journalArticlepeer-review

63 Scopus citations


The clinical course of COVID-19 in pediatric solid organ transplant recipients remains ambiguous. Though preliminary experiences with adult transplant recipients have been published, literature centered on the pediatric population is limited. We herein report a multi-center, multi-organ cohort analysis of COVID-19-positive transplant recipients ≤ 18 years at time of transplant. Data were collected via institutions’ respective electronic medical record systems. Local review boards approved this cross-institutional study. Among 5 transplant centers, 26 patients (62% male) were reviewed with a median age of 8 years. Six were heart recipients, 8 kidney, 10 liver, and 2 lung. Presenting symptoms included cough (n = 12 (46%)), fever (n = 9 (35%)), dry/sore throat (n = 3 (12%)), rhinorrhea (n = 3 (12%)), anosmia (n = 2 (8%)), chest pain (n = 2 (8%)), diarrhea (n = 2 (8%)), dyspnea (n = 1 (4%)), and headache (n = 1 (4%)). Six patients (23%) were asymptomatic. No patient required supplemental oxygen, intubation, or ECMO. Eight patients (31%) were hospitalized at time of diagnosis, 3 of whom were already admitted for unrelated problems. Post-transplant immunosuppression was reduced for only 2 patients (8%). All symptomatic patients recovered within 7 days. Our multi-institutional experience suggests the prognoses of pediatric transplant recipients infected with COVID-19 may mirror those of immunocompetent children, with infrequent hospitalization and minimal treatment, if any, required.

Original languageEnglish (US)
Article numbere13868
JournalPediatric Transplantation
Issue number3
StatePublished - May 2021


  • pediatric transplantation
  • viral infection

ASJC Scopus subject areas

  • Transplantation
  • Pediatrics, Perinatology, and Child Health


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