The pathogenesis of the bone disease of multiple myeloma

Claire M. Edwards, Junling Zhuang, Gregory R. Mundy

Research output: Contribution to journalReview articlepeer-review

135 Scopus citations

Abstract

Multiple myeloma is a fatal hematologic malignancy associated with clonal expansion of malignant plasma cells within the bone marrow and the development of a destructive osteolytic bone disease. The principal cellular mechanisms involved in the development of myeloma bone disease are an increase in osteoclastic bone resorption, and a reduction in bone formation. Myeloma cells are found in close association with sites of active bone resorption, and the interactions between myeloma cells and other cells within the specialized bone marrow microenvironment are essential, both for tumor growth and the development of myeloma bone disease. This review discusses the many different factors which have been implicated in myeloma bone disease, including the evidence for their role in myeloma and subsequent therapeutic implications.

Original languageEnglish (US)
Pages (from-to)1007-1013
Number of pages7
JournalBone
Volume42
Issue number6
DOIs
StatePublished - Jun 2008
Externally publishedYes

Keywords

  • Dkk1
  • Multiple myeloma
  • Osteoblast
  • Osteoclast
  • RANKL

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Histology

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