The p53 tumor suppressor gene in breast cancer

Richard M. Elledge, D. Craig Allred

Research output: Contribution to journalArticlepeer-review

141 Scopus citations

Abstract

Alterations of the p53 tumor suppressor gene are the most common genetic changes found so far in breast cancer, suggesting that the gene plays a central role in the development of the disease. p53 functions as a negative regulator of cell growth, and alterations in the gene lead to loss of this negative growth regulation and more rapid cell proliferation. A number of independent groups using different methods of detection have shown that p53 alterations are associated with more aggressive tumor biologic factors and a poorer prognosis in breast cancer patients. Because of its possible role in the regulation of apoptosis and response to DNA damage, p53 status could also be a predictive marker for response to hormonal or chemotherapy.

Original languageEnglish (US)
Pages (from-to)39-47
Number of pages9
JournalBreast Cancer Research and Treatment
Volume32
Issue number1
DOIs
StatePublished - Jan 1994

Keywords

  • breast cancer
  • p53 gene
  • p53 protein
  • prognosis
  • therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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