The Oxidant/Antioxidant network: Role of melatonin

Russel J Reiter, D. X. Tan, J. Cabrera, D. D'Arpa, R. M. Sainz, J. C. Mayo, S. Ramos

Research output: Contribution to journalArticle

242 Citations (Scopus)

Abstract

Melatonin is now known to be a multifaceted free radical scavenger and antioxidant. It detoxifies a variety of free radicals and reactive oxygen intermediates including the hydroxyl radical, peroxynitrite anion, singlet oxygen and nitric oxide. Additionally, it reportedly stimulates several antioxidative enzymes including glutathione peroxidase, glutathione reductase, glucose-6-phosphate dehydrogenase and superoxide dismutase; conversely, it inhibits a prooxidative enzyme, nitric oxide synthase. Melatonin also crosses all morphophysiological barriers, e.g., the blood-brain barrier, placenta, and distributes throughout the cell; these features increase the efficacy of melatonin as an antioxidant. Melatonin has been shown to markedly protect both membrane lipids and nuclear DNA from oxidative damage. In every experimental model in which melatonin has been tested, it has been found to resist macromolecular damage and the associated dysfunction associated with free radicals.

Original languageEnglish (US)
Pages (from-to)56-63
Number of pages8
JournalBiological Signals and Receptors
Volume8
Issue number1-2
StatePublished - 1999

Fingerprint

Melatonin
Oxidants
Antioxidants
Free Radicals
Singlet Oxygen
Free Radical Scavengers
Peroxynitrous Acid
Glutathione Reductase
Glucosephosphate Dehydrogenase
Enzymes
Membrane Lipids
Glutathione Peroxidase
Blood-Brain Barrier
Nitric Oxide Synthase
Hydroxyl Radical
Placenta
DNA Damage
Superoxide Dismutase
Anions
Nitric Oxide

Keywords

  • Antioxidative defense system
  • Free radicals
  • Melatonin
  • Oxidative stress
  • Oxygen metabolism

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Reiter, R. J., Tan, D. X., Cabrera, J., D'Arpa, D., Sainz, R. M., Mayo, J. C., & Ramos, S. (1999). The Oxidant/Antioxidant network: Role of melatonin. Biological Signals and Receptors, 8(1-2), 56-63.

The Oxidant/Antioxidant network : Role of melatonin. / Reiter, Russel J; Tan, D. X.; Cabrera, J.; D'Arpa, D.; Sainz, R. M.; Mayo, J. C.; Ramos, S.

In: Biological Signals and Receptors, Vol. 8, No. 1-2, 1999, p. 56-63.

Research output: Contribution to journalArticle

Reiter, RJ, Tan, DX, Cabrera, J, D'Arpa, D, Sainz, RM, Mayo, JC & Ramos, S 1999, 'The Oxidant/Antioxidant network: Role of melatonin', Biological Signals and Receptors, vol. 8, no. 1-2, pp. 56-63.
Reiter RJ, Tan DX, Cabrera J, D'Arpa D, Sainz RM, Mayo JC et al. The Oxidant/Antioxidant network: Role of melatonin. Biological Signals and Receptors. 1999;8(1-2):56-63.
Reiter, Russel J ; Tan, D. X. ; Cabrera, J. ; D'Arpa, D. ; Sainz, R. M. ; Mayo, J. C. ; Ramos, S. / The Oxidant/Antioxidant network : Role of melatonin. In: Biological Signals and Receptors. 1999 ; Vol. 8, No. 1-2. pp. 56-63.
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