The origin of urinary stones

Timothy Y. Tseng, Marshall L. Stoller

Research output: Contribution to journalReview articlepeer-review


Urinary stone disease has historically been viewed as a disorder of mineral metabolism leading to precipitation of minerals out of the urine. Therefore, the medical management of urinary stones has focused on improving the urinary milieu. A growing body of evidence suggests that both cardiovascular risk factors and cardiovascular disease itself are associated with the development of urinary stones. Although disorders of mineral metabolism and cardiovascular diseases are both systemic conditions, patients frequently present with asymmetric renal calculus disease, suggesting that as yet uncharacterized local mechanisms must contribute to the formation of renal calculi. In this review, we examine the links between cardiovascular disease and nephrolithiasis, and discuss the evidence for potential local factors that contribute to stone disease.

Original languageEnglish (US)
Pages (from-to)65-69
Number of pages5
JournalUrological Science
Issue number2
StatePublished - Jun 2010
Externally publishedYes


  • Atherosclerosis
  • Kidney stone
  • Metabolic syndrome
  • Nephrolithiasis
  • Vascular diseases

ASJC Scopus subject areas

  • Urology


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