The organochlorine insecticide 1,2,3,4,5,6-hexachlorocyclohexane (lindane) but not 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) augments the nocturnal increase in pineal N-acetyltransferase activity and pineal and serum melatonin levels

A. M. Attia, M. H. Mostafa, S. A. Soliman, A. H. El-Sebae, K. O. Nonaka, B. Withyachumnarnkul, Russel J Reiter

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The effect of organochlorine insecticides lindane (1,2,3,4,5,6-hexachlorocyclohexane) and DDT (1,1,1-trichloro-2,2-bis (p-chlorophenyl)ethane) were studied in terms of their effects on the rat pineal N-acetyltransferase (NAT) activity, hydroxyindole-O-methyltransferase (HIOMT) activity and pineal and serum melatonin levels during the day (2000h) and at night (2300 and 0100h). Additionally, pineal levels of 5-hydroxytryptophan (5-HTP), serotonin (5-HT), and 5-hydroxyindole acetic acid (5-HIAA) were estimated. Nocturnal NAT activity was increased after lindane administration; likewise, lindane augmented pineal and serum melatonin levels at 2300h. Conversely, DDT was without a statistically significant effect on either NAT activity or on pineal or serum melatonin levels. Neither lindane nor DDT significantly influenced pineal HIOMT values either during the day or at night. Likewise, neither insecticide consistently influenced pineal levels of either 5-HTP, 5-HT or 5-HIAA. The results indicate that the organochlorine insecticide, lindane, modifies pineal melatonin synthesis in vivo.

Original languageEnglish (US)
Pages (from-to)673-680
Number of pages8
JournalNeurochemical Research
Volume15
Issue number7
DOIs
StatePublished - Jul 1990

Fingerprint

Lindane
Acetyltransferases
DDT
Melatonin
Insecticides
Acetylserotonin O-Methyltransferase
Serum
5-Hydroxytryptophan
Serotonin
Acetic Acid
Rats

Keywords

  • DDT
  • hydroxyindole-O-methyltransferase (HIOMT)
  • lindane
  • melatonin
  • N-acetyltransferase (NAT)
  • Pineal gland

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry

Cite this

The organochlorine insecticide 1,2,3,4,5,6-hexachlorocyclohexane (lindane) but not 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) augments the nocturnal increase in pineal N-acetyltransferase activity and pineal and serum melatonin levels. / Attia, A. M.; Mostafa, M. H.; Soliman, S. A.; El-Sebae, A. H.; Nonaka, K. O.; Withyachumnarnkul, B.; Reiter, Russel J.

In: Neurochemical Research, Vol. 15, No. 7, 07.1990, p. 673-680.

Research output: Contribution to journalArticle

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abstract = "The effect of organochlorine insecticides lindane (1,2,3,4,5,6-hexachlorocyclohexane) and DDT (1,1,1-trichloro-2,2-bis (p-chlorophenyl)ethane) were studied in terms of their effects on the rat pineal N-acetyltransferase (NAT) activity, hydroxyindole-O-methyltransferase (HIOMT) activity and pineal and serum melatonin levels during the day (2000h) and at night (2300 and 0100h). Additionally, pineal levels of 5-hydroxytryptophan (5-HTP), serotonin (5-HT), and 5-hydroxyindole acetic acid (5-HIAA) were estimated. Nocturnal NAT activity was increased after lindane administration; likewise, lindane augmented pineal and serum melatonin levels at 2300h. Conversely, DDT was without a statistically significant effect on either NAT activity or on pineal or serum melatonin levels. Neither lindane nor DDT significantly influenced pineal HIOMT values either during the day or at night. Likewise, neither insecticide consistently influenced pineal levels of either 5-HTP, 5-HT or 5-HIAA. The results indicate that the organochlorine insecticide, lindane, modifies pineal melatonin synthesis in vivo.",
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