The 'open artery hypothesis' in survivors of myocardial infarction

William R. Pitts, Joaquin E. Cigarroa, Richard A. Lange, L. David Hillis

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

In survivors of acute myocardial infarction, the restoration of antegrade flow in the infarct-related coronary artery may improve prognosis by a mechanism independent of its effect on left ventricular function. Survival may be enhanced even when restoration of flow is accomplished days or weeks after the acute event. In a series of retrospective studies of survivors of a first myocardial infarction, it was shown that long-term survival is significantly better in those with than in those without antegrade flow in the infarct-related artery. It is hypothesized that late restoration of antegrade flow in the infarct-related artery renders the border zone of the infarction more electrically stable, thereby diminishing the incidence of ventricular tachyarrhythmias and sudden death.

Original languageEnglish (US)
Pages (from-to)522-524
Number of pages3
JournalClinical Cardiology
Volume20
Issue number6
DOIs
StatePublished - 1997

Keywords

  • Infarct artery
  • Patency

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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