The olfactory bulb: A metabolic sensor of brain insulin and glucose concentrations via a voltage-gated potassium channel

Kristal Tucker, Melissa Ann Cavallin, Patrick Jean-Baptiste, K. C. Biju, James Michael Overton, Paola Pedarzani, Debra Ann Fadool

Research output: Chapter in Book/Report/Conference proceedingChapter

26 Scopus citations

Abstract

The voltage-gated potassium channel, Kv1.3, contributes a large proportion of the current in mitral cell neurons of the olfactory bulb where it assists to time the firing patterns of action potentials as spike clusters that are important for odorant detection. Gene-targeted deletion of the Kv1.3 channel, produces a "super-smeller" phenotype, whereby mice are additionally resistant to diet- and genetically-induced obesity. As assessed via an electrophysiological slice preparation of the olfactory bulb, Kv1.3 is modulated via energetically important molecules - such as insulin and glucose - contributing to the body's metabolic response to fat intake. We discuss a biophysical characterization of modulated synaptic communication in the slice following acute glucose and insulin stimulation, chronic elevation of insulin in mice that are in a conscious state, and induction of diet-induced obesity. We have discovered that Kv1.3 contributes an unusual nonconducting role - the detection of metabolic state.

Original languageEnglish (US)
Title of host publicationSensory and Metabolic Control of Energy Balance
EditorsWolfgang Meyerhof, Hans-Georg Joost, Ulrike Beisiegel
Pages147-157
Number of pages11
DOIs
StatePublished - 2010
Externally publishedYes

Publication series

NameResults and Problems in Cell Differentiation
Volume52
ISSN (Print)0080-1844
ISSN (Electronic)1861-0412

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'The olfactory bulb: A metabolic sensor of brain insulin and glucose concentrations via a voltage-gated potassium channel'. Together they form a unique fingerprint.

  • Cite this

    Tucker, K., Cavallin, M. A., Jean-Baptiste, P., Biju, K. C., Overton, J. M., Pedarzani, P., & Fadool, D. A. (2010). The olfactory bulb: A metabolic sensor of brain insulin and glucose concentrations via a voltage-gated potassium channel. In W. Meyerhof, H-G. Joost, & U. Beisiegel (Eds.), Sensory and Metabolic Control of Energy Balance (pp. 147-157). (Results and Problems in Cell Differentiation; Vol. 52). https://doi.org/10.1007/978-3-642-14426-4_12