The neuropathogenesis of AIDS

Francisco González-Scarano, Julio Martín-García

Research output: Contribution to journalReview article

812 Scopus citations

Abstract

HIV-associated dementia (HAD) is an important complication of the central nervous system in patients who are infected with HIV-1. Although the incidence of HAD has markedly decreased since it has become possible to effectively control viral replication in the blood by administering highly active antiretroviral therapy, a less severe form of HAD, comprising a milder cognitive and motor disorder, is now potentially a serious problem. Brain macrophages and microglia are the key cell types that are infected by HIV-1 in the central nervous system, and they are likely to mediate the neurodegeneration seen in patients with HAD; however, the precise pathogenesis of this neurodegeneration is still unclear. Here, we discuss the studies that are being carried out to determine the respective contributions of infection, and monocyte and macrophage activation, to disease progression.

Original languageEnglish (US)
Pages (from-to)69-81
Number of pages13
JournalNature Reviews Immunology
Volume5
Issue number1
DOIs
StatePublished - Jan 1 2005

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    González-Scarano, F., & Martín-García, J. (2005). The neuropathogenesis of AIDS. Nature Reviews Immunology, 5(1), 69-81. https://doi.org/10.1038/nri1527