TY - JOUR
T1 - The neuropathogenesis of AIDS
AU - González-Scarano, Francisco
AU - Martín-García, Julio
N1 - Funding Information:
We are supported by grants from the National Institute of Neurological Disorders and Stroke (United States) and the National Institute of Mental Health (United States). We regret that space constraints prevented the inclusion of important findings by many of our colleagues.
PY - 2005/1
Y1 - 2005/1
N2 - HIV-associated dementia (HAD) is an important complication of the central nervous system in patients who are infected with HIV-1. Although the incidence of HAD has markedly decreased since it has become possible to effectively control viral replication in the blood by administering highly active antiretroviral therapy, a less severe form of HAD, comprising a milder cognitive and motor disorder, is now potentially a serious problem. Brain macrophages and microglia are the key cell types that are infected by HIV-1 in the central nervous system, and they are likely to mediate the neurodegeneration seen in patients with HAD; however, the precise pathogenesis of this neurodegeneration is still unclear. Here, we discuss the studies that are being carried out to determine the respective contributions of infection, and monocyte and macrophage activation, to disease progression.
AB - HIV-associated dementia (HAD) is an important complication of the central nervous system in patients who are infected with HIV-1. Although the incidence of HAD has markedly decreased since it has become possible to effectively control viral replication in the blood by administering highly active antiretroviral therapy, a less severe form of HAD, comprising a milder cognitive and motor disorder, is now potentially a serious problem. Brain macrophages and microglia are the key cell types that are infected by HIV-1 in the central nervous system, and they are likely to mediate the neurodegeneration seen in patients with HAD; however, the precise pathogenesis of this neurodegeneration is still unclear. Here, we discuss the studies that are being carried out to determine the respective contributions of infection, and monocyte and macrophage activation, to disease progression.
UR - http://www.scopus.com/inward/record.url?scp=11244271607&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=11244271607&partnerID=8YFLogxK
U2 - 10.1038/nri1527
DO - 10.1038/nri1527
M3 - Review article
C2 - 15630430
AN - SCOPUS:11244271607
SN - 1474-1733
VL - 5
SP - 69
EP - 81
JO - Nature Reviews Immunology
JF - Nature Reviews Immunology
IS - 1
ER -