The nature of schizotypy among multigenerational multiplex schizophrenia families

Sarah I. Tarbox, Laura Almasy, Raquel E. Gur, Vishwajit L. Nimgaonkar, Michael F. Pogue-Geile

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Identification of endophenotypes (Gottesman & Gould, 2003; Gottesman & Shields, 1972) that genetically correlate with schizophrenia and are genetically homogeneous is an important strategy for detecting genes that affect schizophrenia risk. Symptoms of schizotypy may familially correlate with schizophrenia; however, there are critical limitations of the current literature concerning this association. The present study examined the genetic architecture and genetic associations between schizotypy and schizophrenia among multigenerational, multiplex schizophrenia families. Genetic schizotypy factor scales were developed that genetically correlated with schizophrenia, although some relations were unexpected in direction suggesting minimization of "psychotic-like" symptoms. These genetic schizotypy factor scales did not genetically correlate with major depressive disorder or substance dependence indicating specificity to schizophrenia. The results highlight the possibility of significant response bias in schizophrenia families, particularly among close relatives, and suggest an important consideration when acquiring self-report information. This is a topic that deserves future study as the origins of this putative bias in relatives are unclear. In addition, the results support the identification of genetic schizotypy factors as a promising technique for maximizing genetic correlation of endophenotypes with schizophrenia.

Original languageEnglish (US)
Pages (from-to)396-406
Number of pages11
JournalJournal of Abnormal Psychology
Issue number2
StatePublished - 2012
Externally publishedYes


  • Behavior genetics
  • Endophenotype
  • Factor analysis
  • Relatives
  • Schizotypal

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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