The natural history of isolated left ventricular diastolic dysfunction

Walter C. Brogan, L. David Hillis, Eduardo D. Flores, Richard A. Lange

Research output: Contribution to journalArticlepeer-review

99 Scopus citations


study objective: To assess the natural history of isolated left ventricular diastolic dysfunction. materials and methods: Follow-up (average duration, 68 months) was obtained in 51 patients with isolated left ventricular diastolic dysfunction at cardiac catheterization, characterized by (1) an elevated left ventricular end-diastolic pressure; (2) normal left ventricular end-diastolic and end-systolic volumes; (3) normal left ventricular ejection fraction; (4) no coronary artery disease; and (5) no valvular disease. results: During follow-up, seven patients died, but only one died of cardiac causes. Of the 44 living subjects, 20 (45%) noted new-onset symptoms of congestive heart failure, with 11 (25%) of these requiring hospitalization, and 12 (27%) required hospitalization for recurrent chest pain. conclusion: Isolated left ventricular diastolic dysfunction is associated with a low cardiac mortality; at the same time, however, it is associated with substantial morbidity.

Original languageEnglish (US)
Pages (from-to)627-630
Number of pages4
JournalThe American Journal of Medicine
Issue number6
StatePublished - Jun 1992
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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