The multiple functions of melatonin in regenerative medicine

Maryam Majidinia; Russel J. Reiter; Seyed Kazem Shakouri; Iraj Mohebbi; Mojgan Rastegar; Mojtaba Kaviani; Saber Ghazizadeh Darband; Rana Jahanban-Esfahlan; Seyed Mohammad Nabavi; Bahman Yousefi

doi:10.1016/j.arr.2018.04.003

The multiple functions of melatonin in regenerative medicine

Maryam Majidinia, Russel J. Reiter, Seyed Kazem Shakouri, Iraj Mohebbi, Mojgan Rastegar, Mojtaba Kaviani, Saber Ghazizadeh Darband, Rana Jahanban-Esfahlan, Seyed Mohammad Nabavi, Bahman Yousefi

Department of Cell Systems & Anatomy

Research output: Contribution to journal › Review article › peer-review

80 Scopus citations

Abstract

Melatonin research has been experiencing hyper growth in the last two decades; this relates to its numerous physiological functions including anti-inflammation, oncostasis, circadian and endocrine rhythm regulation, and its potent antioxidant activity. Recently, a large number of studies have focused on the role of melatonin in the regeneration of cells or tissues after their partial loss. In this review, we discuss the recent findings on the molecular involvement of melatonin in the regeneration of various tissues including the nervous system, liver, bone, kidney, bladder, skin, and muscle, among others.

Original language	English (US)
Pages (from-to)	33-52
Number of pages	20
Journal	Ageing Research Reviews
Volume	45
DOIs	https://doi.org/10.1016/j.arr.2018.04.003
State	Published - Aug 2018

Keywords

Bone regeneration
Circadian rhythm
Kidney regeneration
Liver regeneration
Muscle regeneration
Neuroregeneration
Stem cell
Tissue engineering

ASJC Scopus subject areas

Neurology
Aging
Molecular Biology
Biochemistry
Biotechnology

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10.1016/j.arr.2018.04.003

Cite this

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title = "The multiple functions of melatonin in regenerative medicine",

abstract = "Melatonin research has been experiencing hyper growth in the last two decades; this relates to its numerous physiological functions including anti-inflammation, oncostasis, circadian and endocrine rhythm regulation, and its potent antioxidant activity. Recently, a large number of studies have focused on the role of melatonin in the regeneration of cells or tissues after their partial loss. In this review, we discuss the recent findings on the molecular involvement of melatonin in the regeneration of various tissues including the nervous system, liver, bone, kidney, bladder, skin, and muscle, among others.",

keywords = "Bone regeneration, Circadian rhythm, Kidney regeneration, Liver regeneration, Muscle regeneration, Neuroregeneration, Stem cell, Tissue engineering",

author = "Maryam Majidinia and Reiter, {Russel J.} and Shakouri, {Seyed Kazem} and Iraj Mohebbi and Mojgan Rastegar and Mojtaba Kaviani and Darband, {Saber Ghazizadeh} and Rana Jahanban-Esfahlan and Nabavi, {Seyed Mohammad} and Bahman Yousefi",

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doi = "10.1016/j.arr.2018.04.003",

language = "English (US)",

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AU - Majidinia, Maryam

AU - Reiter, Russel J.

AU - Shakouri, Seyed Kazem

AU - Mohebbi, Iraj

AU - Rastegar, Mojgan

AU - Kaviani, Mojtaba

AU - Darband, Saber Ghazizadeh

AU - Jahanban-Esfahlan, Rana

AU - Nabavi, Seyed Mohammad

AU - Yousefi, Bahman

PY - 2018/8

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AB - Melatonin research has been experiencing hyper growth in the last two decades; this relates to its numerous physiological functions including anti-inflammation, oncostasis, circadian and endocrine rhythm regulation, and its potent antioxidant activity. Recently, a large number of studies have focused on the role of melatonin in the regeneration of cells or tissues after their partial loss. In this review, we discuss the recent findings on the molecular involvement of melatonin in the regeneration of various tissues including the nervous system, liver, bone, kidney, bladder, skin, and muscle, among others.

KW - Bone regeneration

KW - Circadian rhythm

KW - Kidney regeneration

KW - Liver regeneration

KW - Muscle regeneration

KW - Neuroregeneration

KW - Stem cell

KW - Tissue engineering

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The multiple functions of melatonin in regenerative medicine

Abstract

Keywords

ASJC Scopus subject areas

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