The multiple functions of melatonin in regenerative medicine

Maryam Majidinia, Russel J. Reiter, Seyed Kazem Shakouri, Iraj Mohebbi, Mojgan Rastegar, Mojtaba Kaviani, Saber Ghazizadeh Darband, Rana Jahanban-Esfahlan, Seyed Mohammad Nabavi, Bahman Yousefi

Research output: Contribution to journalReview articlepeer-review

52 Scopus citations


Melatonin research has been experiencing hyper growth in the last two decades; this relates to its numerous physiological functions including anti-inflammation, oncostasis, circadian and endocrine rhythm regulation, and its potent antioxidant activity. Recently, a large number of studies have focused on the role of melatonin in the regeneration of cells or tissues after their partial loss. In this review, we discuss the recent findings on the molecular involvement of melatonin in the regeneration of various tissues including the nervous system, liver, bone, kidney, bladder, skin, and muscle, among others.

Original languageEnglish (US)
Pages (from-to)33-52
Number of pages20
JournalAgeing Research Reviews
StatePublished - Aug 2018


  • Bone regeneration
  • Circadian rhythm
  • Kidney regeneration
  • Liver regeneration
  • Muscle regeneration
  • Neuroregeneration
  • Stem cell
  • Tissue engineering

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Aging
  • Molecular Biology
  • Neurology


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