The MTHFD1L gene rs11754661 marker is not associated with Alzheimer's disease in a sample of the Spanish population

Reposo Ramírez-Lorca; Mercé Boada; Carmen Antúnez; Jesús López-Arrieta; Concha Moreno-Rey; Isabel Hernández; Juan Marín; Javier Gayán; Antonio González-Pérez; Montserrat Alegret; Lluis Tárraga; Luis M. Real; Agustín Ruiz

doi:10.3233/JAD-2011-101983

The MTHFD1L gene rs11754661 marker is not associated with Alzheimer's disease in a sample of the Spanish population

Reposo Ramírez-Lorca, Mercé Boada, Carmen Antúnez, Jesús López-Arrieta, Concha Moreno-Rey, Isabel Hernández, Juan Marín, Javier Gayán, Antonio González-Pérez, Montserrat Alegret, Lluis Tárraga, Luis M. Real, Agustín Ruiz

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The MTHFD1L gene SNP variant rs11754661 was found to increase the risk of Alzheimer's disease in a recent Whole Genome Association Study [1]. We have carried out an independent study of this genetic variant in 2467 individuals from Spain. We found no evidence of association between the MTHFD1L marker and susceptibility to Alzheimer's disease in our sample.

Original language	English (US)
Pages (from-to)	47-50
Number of pages	4
Journal	Journal of Alzheimer's Disease
Volume	25
Issue number	1
DOIs	https://doi.org/10.3233/JAD-2011-101983
State	Published - 2011
Externally published	Yes

Keywords

Folate
GWAS
homocysteine
MTHFD1L
population genetics
SNP
susceptibility

ASJC Scopus subject areas

General Neuroscience
Clinical Psychology
Geriatrics and Gerontology
Psychiatry and Mental health

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10.3233/JAD-2011-101983

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Ramírez-Lorca, R., Boada, M., Antúnez, C., López-Arrieta, J., Moreno-Rey, C., Hernández, I., Marín, J., Gayán, J., González-Pérez, A., Alegret, M., Tárraga, L., Real, L. M., & Ruiz, A. (2011). The MTHFD1L gene rs11754661 marker is not associated with Alzheimer's disease in a sample of the Spanish population. Journal of Alzheimer's Disease, 25(1), 47-50. https://doi.org/10.3233/JAD-2011-101983

Ramírez-Lorca, R, Boada, M, Antúnez, C, López-Arrieta, J, Moreno-Rey, C, Hernández, I, Marín, J, Gayán, J, González-Pérez, A, Alegret, M, Tárraga, L, Real, LM & Ruiz, A 2011, 'The MTHFD1L gene rs11754661 marker is not associated with Alzheimer's disease in a sample of the Spanish population', Journal of Alzheimer's Disease, vol. 25, no. 1, pp. 47-50. https://doi.org/10.3233/JAD-2011-101983

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abstract = "The MTHFD1L gene SNP variant rs11754661 was found to increase the risk of Alzheimer's disease in a recent Whole Genome Association Study [1]. We have carried out an independent study of this genetic variant in 2467 individuals from Spain. We found no evidence of association between the MTHFD1L marker and susceptibility to Alzheimer's disease in our sample.",

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doi = "10.3233/JAD-2011-101983",

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AU - Ramírez-Lorca, Reposo

AU - Boada, Mercé

AU - Antúnez, Carmen

AU - López-Arrieta, Jesús

AU - Moreno-Rey, Concha

AU - Hernández, Isabel

AU - Marín, Juan

AU - Gayán, Javier

AU - González-Pérez, Antonio

AU - Alegret, Montserrat

AU - Tárraga, Lluis

AU - Real, Luis M.

AU - Ruiz, Agustín

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KW - homocysteine

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KW - population genetics

KW - SNP

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The MTHFD1L gene rs11754661 marker is not associated with Alzheimer's disease in a sample of the Spanish population

Abstract

Keywords

ASJC Scopus subject areas

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