The mouse lysyl oxidase-like 2 gene (mLOXL2) maps to chromosome 14 and is highly expressed in skin, lung and thymus

Claude Jourdan-Le Saux; Olivier Le Saux; Claudine Gleyzal; Pascal Sommer; Katalin Csiszar

doi:10.1016/S0945-053X(00)00061-5

The mouse lysyl oxidase-like 2 gene (mLOXL2) maps to chromosome 14 and is highly expressed in skin, lung and thymus

Claude Jourdan-Le Saux, Olivier Le Saux, Claudine Gleyzal, Pascal Sommer, Katalin Csiszar

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The predicted amino acid sequence derived from a mouse expressed sequence tag (EST) contig contained two domains that are highly conserved among members of the lysyl oxidase gene family: a copper binding-site with four histidines and a catalytic domain that includes a tryptophan residue. This new cDNA sequence showed the highest level of sequence homology with the human loxl2 cDNA and suggested that it encoded the mouse equivalent of hLOXL2. The mLOXL2 gene was mapped to chromosome 14 by radiation hybrid analysis. The mLOXL2 locus was tightly linked with a LOD score over 9 to the marker D14Mit32. The mLOXL2 gene is expressed as a 4-kb mRNA in almost all tissues analyzed, with highest levels of mRNA in skin, lung and thymus. (C) 2000 Elsevier Science B.V./International Society of Matrix Biology.

Original language	English (US)
Pages (from-to)	179-183
Number of pages	5
Journal	Matrix Biology
Volume	19
Issue number	2
DOIs	https://doi.org/10.1016/S0945-053X(00)00061-5
State	Published - May 1 2000
Externally published	Yes

Keywords

Lysyl oxidase
Mouse
mLOXL2 gene

ASJC Scopus subject areas

Molecular Biology

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10.1016/S0945-053X(00)00061-5

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title = "The mouse lysyl oxidase-like 2 gene (mLOXL2) maps to chromosome 14 and is highly expressed in skin, lung and thymus",

abstract = "The predicted amino acid sequence derived from a mouse expressed sequence tag (EST) contig contained two domains that are highly conserved among members of the lysyl oxidase gene family: a copper binding-site with four histidines and a catalytic domain that includes a tryptophan residue. This new cDNA sequence showed the highest level of sequence homology with the human loxl2 cDNA and suggested that it encoded the mouse equivalent of hLOXL2. The mLOXL2 gene was mapped to chromosome 14 by radiation hybrid analysis. The mLOXL2 locus was tightly linked with a LOD score over 9 to the marker D14Mit32. The mLOXL2 gene is expressed as a 4-kb mRNA in almost all tissues analyzed, with highest levels of mRNA in skin, lung and thymus. (C) 2000 Elsevier Science B.V./International Society of Matrix Biology.",

keywords = "Lysyl oxidase, Mouse, mLOXL2 gene",

author = "{Jourdan-Le Saux}, Claude and {Le Saux}, Olivier and Claudine Gleyzal and Pascal Sommer and Katalin Csiszar",

note = "Funding Information: This work was supported by NIH grants CA766580 and RR03061.",

year = "2000",

month = may,

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doi = "10.1016/S0945-053X(00)00061-5",

language = "English (US)",

volume = "19",

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T1 - The mouse lysyl oxidase-like 2 gene (mLOXL2) maps to chromosome 14 and is highly expressed in skin, lung and thymus

AU - Jourdan-Le Saux, Claude

AU - Le Saux, Olivier

AU - Gleyzal, Claudine

AU - Sommer, Pascal

AU - Csiszar, Katalin

N1 - Funding Information: This work was supported by NIH grants CA766580 and RR03061.

PY - 2000/5/1

Y1 - 2000/5/1

N2 - The predicted amino acid sequence derived from a mouse expressed sequence tag (EST) contig contained two domains that are highly conserved among members of the lysyl oxidase gene family: a copper binding-site with four histidines and a catalytic domain that includes a tryptophan residue. This new cDNA sequence showed the highest level of sequence homology with the human loxl2 cDNA and suggested that it encoded the mouse equivalent of hLOXL2. The mLOXL2 gene was mapped to chromosome 14 by radiation hybrid analysis. The mLOXL2 locus was tightly linked with a LOD score over 9 to the marker D14Mit32. The mLOXL2 gene is expressed as a 4-kb mRNA in almost all tissues analyzed, with highest levels of mRNA in skin, lung and thymus. (C) 2000 Elsevier Science B.V./International Society of Matrix Biology.

AB - The predicted amino acid sequence derived from a mouse expressed sequence tag (EST) contig contained two domains that are highly conserved among members of the lysyl oxidase gene family: a copper binding-site with four histidines and a catalytic domain that includes a tryptophan residue. This new cDNA sequence showed the highest level of sequence homology with the human loxl2 cDNA and suggested that it encoded the mouse equivalent of hLOXL2. The mLOXL2 gene was mapped to chromosome 14 by radiation hybrid analysis. The mLOXL2 locus was tightly linked with a LOD score over 9 to the marker D14Mit32. The mLOXL2 gene is expressed as a 4-kb mRNA in almost all tissues analyzed, with highest levels of mRNA in skin, lung and thymus. (C) 2000 Elsevier Science B.V./International Society of Matrix Biology.

KW - Lysyl oxidase

KW - Mouse

KW - mLOXL2 gene

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ER -

The mouse lysyl oxidase-like 2 gene (mLOXL2) maps to chromosome 14 and is highly expressed in skin, lung and thymus

Abstract

Keywords

ASJC Scopus subject areas

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