The mouse lysyl oxidase-like 2 gene (mLOXL2) maps to chromosome 14 and is highly expressed in skin, lung and thymus

Claude Jourdan-Le Saux, Olivier Le Saux, Claudine Gleyzal, Pascal Sommer, Katalin Csiszar

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

The predicted amino acid sequence derived from a mouse expressed sequence tag (EST) contig contained two domains that are highly conserved among members of the lysyl oxidase gene family: a copper binding-site with four histidines and a catalytic domain that includes a tryptophan residue. This new cDNA sequence showed the highest level of sequence homology with the human loxl2 cDNA and suggested that it encoded the mouse equivalent of hLOXL2. The mLOXL2 gene was mapped to chromosome 14 by radiation hybrid analysis. The mLOXL2 locus was tightly linked with a LOD score over 9 to the marker D14Mit32. The mLOXL2 gene is expressed as a 4-kb mRNA in almost all tissues analyzed, with highest levels of mRNA in skin, lung and thymus. (C) 2000 Elsevier Science B.V./International Society of Matrix Biology.

Original languageEnglish (US)
Pages (from-to)179-183
Number of pages5
JournalMatrix Biology
Volume19
Issue number2
DOIs
StatePublished - May 1 2000
Externally publishedYes

Keywords

  • Lysyl oxidase
  • Mouse
  • mLOXL2 gene

ASJC Scopus subject areas

  • Molecular Biology

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