The molecular basis of selective permeability of connexins is complex and includes both size and charge

B. J. Nicholson, P. A. Weber, F. Cao, H. C. Chang, P. Lampe, G. Goldberg

Research output: Contribution to journalArticle

101 Scopus citations

Abstract

Although gap junction channels are still widely viewed as large, non-specific pores connecting cells, the diversity in the connexin family has led more attention to be focused on their permeability characteristics. We summarize here the current status of these investigations, both published and on-going, that reveal both charge and size selectivity between gap junction channels composed of different connexins. In particular, this review will focus on quantitative approaches that monitor the expression level of the connexins, so that it is clear that differences that are seen can be attributed to channel properties. The degree of selectivity that is observed is modest compared to other channels, but is likely to be significant for biological molecules that are labile within the cell. Of particular relevance to the in vivo function of gap junctions, recent studies are summarized that demonstrate that the connexin phenotype can control the nature of the endogenous traffic between cells, with consequent effects on biological effects of gap junctions such as tumor suppression.

Original languageEnglish (US)
Pages (from-to)369-378
Number of pages10
JournalBrazilian Journal of Medical and Biological Research
Volume33
Issue number4
DOIs
Publication statusPublished - Apr 2000

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Keywords

  • Channel selectivity
  • Gap junctions
  • Intercellular channels
  • Permeability

ASJC Scopus subject areas

  • Biophysics
  • Neuroscience(all)
  • Biochemistry
  • Physiology
  • Immunology
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Cell Biology

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