The Molecular Basis of Predicting Atherosclerotic Cardiovascular Disease Risk

Matthew Nayor, Kemar J. Brown, Ramachandran S. Vasan

Research output: Contribution to journalReview articlepeer-review

47 Scopus citations


Atherosclerotic cardiovascular disease (ASCVD) proceeds through a series of stages: initiation, progression (or regression), and complications. By integrating known biology regarding molecular signatures of each stage with recent advances in high-dimensional molecular data acquisition platforms (to assay the genome, epigenome, transcriptome, proteome, metabolome, and gut microbiome), snapshots of each phase of atherosclerotic cardiovascular disease development can be captured. In this review, we will summarize emerging approaches for assessment of atherosclerotic cardiovascular disease risk in humans using peripheral blood molecular signatures and molecular imaging approaches. We will then discuss the potential (and challenges) for these snapshots to be integrated into a personalized movie providing dynamic readouts of an individual's atherosclerotic cardiovascular disease risk status throughout the life course.

Original languageEnglish (US)
Pages (from-to)287-303
Number of pages17
JournalCirculation research
Issue number2
StatePublished - Jan 22 2021
Externally publishedYes


  • cardiovascular disease
  • coronary artery disease
  • metabolome
  • proteomics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology


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