The mitochondrial p53 pathway

Angelina V. Vaseva, Ute M. Moll

Research output: Contribution to journalReview articlepeer-review

448 Scopus citations

Abstract

p53 is one of the most mutated tumor suppressors in human cancers and as such has been intensively studied for a long time. p53 is a major orchestrator of the cellular response to a broad array of stress types by regulating apoptosis, cell cycle arrest, senescence, DNA repair and genetic stability. For a long time it was thought that these functions of p53 solely rely on its function as a transcription factor, and numerous p53 target genes have been identified [1]. In the last 8 years however, a novel transcription-independent proapoptotic function mediated by the cytoplasmic pool of p53 has been revealed. p53 participates directly in the intrinsic apoptosis pathway by interacting with the multidomain members of the Bcl-2 family to induce mitochondrial outer membrane permeabilization. Our review will discuss these studies, focusing on recent advances in the field.

Original languageEnglish (US)
Pages (from-to)414-420
Number of pages7
JournalBiochimica et Biophysica Acta - Bioenergetics
Volume1787
Issue number5
DOIs
StatePublished - May 2009
Externally publishedYes

Keywords

  • Apoptosis
  • Bcl-2 family
  • Ischemia
  • Mitochondria
  • p53
  • Pathophysiology
  • Radiosensitivity
  • Transcription

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology

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