Abstract
p53 is one of the most mutated tumor suppressors in human cancers and as such has been intensively studied for a long time. p53 is a major orchestrator of the cellular response to a broad array of stress types by regulating apoptosis, cell cycle arrest, senescence, DNA repair and genetic stability. For a long time it was thought that these functions of p53 solely rely on its function as a transcription factor, and numerous p53 target genes have been identified [1]. In the last 8 years however, a novel transcription-independent proapoptotic function mediated by the cytoplasmic pool of p53 has been revealed. p53 participates directly in the intrinsic apoptosis pathway by interacting with the multidomain members of the Bcl-2 family to induce mitochondrial outer membrane permeabilization. Our review will discuss these studies, focusing on recent advances in the field.
Original language | English (US) |
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Pages (from-to) | 414-420 |
Number of pages | 7 |
Journal | Biochimica et Biophysica Acta - Bioenergetics |
Volume | 1787 |
Issue number | 5 |
DOIs | |
State | Published - May 2009 |
Externally published | Yes |
Keywords
- Apoptosis
- Bcl-2 family
- Ischemia
- Mitochondria
- Pathophysiology
- Radiosensitivity
- Transcription
- p53
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Cell Biology