The mitochondrial choline transporter, SLC25A48, regulates urine and blood choline levels in humans

Soumya Maity; Kumar Sharma

doi:10.1016/j.kint.2024.11.014

The mitochondrial choline transporter, SLC25A48, regulates urine and blood choline levels in humans

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Choline is an essential nutrient for the biosynthesis of phospholipids and neurotransmitters and controls several physiological functions in mammals. It is metabolized in the organelles within cells, including mitochondria. However, its subcellular distribution and mode of mitochondrial transport remain poorly understood. Patil et al. identified SLC25A48 as a mitochondrial choline transporter, and its loss-of-function mutations were associated with elevated urine and plasma choline levels in humans.

Original language	English (US)
Pages (from-to)	225-227
Number of pages	3
Journal	Kidney international
Volume	107
Issue number	2
DOIs	https://doi.org/10.1016/j.kint.2024.11.014
State	Published - Feb 2025

ASJC Scopus subject areas

Nephrology

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10.1016/j.kint.2024.11.014

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title = "The mitochondrial choline transporter, SLC25A48, regulates urine and blood choline levels in humans",

abstract = "Choline is an essential nutrient for the biosynthesis of phospholipids and neurotransmitters and controls several physiological functions in mammals. It is metabolized in the organelles within cells, including mitochondria. However, its subcellular distribution and mode of mitochondrial transport remain poorly understood. Patil et al. identified SLC25A48 as a mitochondrial choline transporter, and its loss-of-function mutations were associated with elevated urine and plasma choline levels in humans.",

author = "Soumya Maity and Kumar Sharma",

note = "Publisher Copyright: {\textcopyright} 2024 International Society of Nephrology",

year = "2025",

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AU - Maity, Soumya

AU - Sharma, Kumar

PY - 2025/2

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N2 - Choline is an essential nutrient for the biosynthesis of phospholipids and neurotransmitters and controls several physiological functions in mammals. It is metabolized in the organelles within cells, including mitochondria. However, its subcellular distribution and mode of mitochondrial transport remain poorly understood. Patil et al. identified SLC25A48 as a mitochondrial choline transporter, and its loss-of-function mutations were associated with elevated urine and plasma choline levels in humans.

AB - Choline is an essential nutrient for the biosynthesis of phospholipids and neurotransmitters and controls several physiological functions in mammals. It is metabolized in the organelles within cells, including mitochondria. However, its subcellular distribution and mode of mitochondrial transport remain poorly understood. Patil et al. identified SLC25A48 as a mitochondrial choline transporter, and its loss-of-function mutations were associated with elevated urine and plasma choline levels in humans.

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U2 - 10.1016/j.kint.2024.11.014

DO - 10.1016/j.kint.2024.11.014

M3 - Comment/debate

C2 - 39848743

AN - SCOPUS:85214564016

SN - 0085-2538

VL - 107

SP - 225

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JO - Kidney international

JF - Kidney international

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ER -

The mitochondrial choline transporter, SLC25A48, regulates urine and blood choline levels in humans

Abstract

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