The Mirizzi syndrome: Multidisciplinary management promotes optimal outcomes

Rozina Mithani, Wayne H. Schwesinger, Juliane Bingener, Kenneth R. Sirinek, Glenn W.W. Gross

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


The Mirizzi syndrome (MS) is a rare cause of obstructive jaundice produced by the impaction of a gallstone either in the cystic duct or in the gallbladder, resulting in stenosis of the extrahepatic bile duct and, in severe cases, direct cholecystocholedochal fistula formation. Sixteen patients were treated for MS in our center over the 12-year period 1993-2005 for a prevalence of 0.35% of all cholecystectomies performed. One patient was diagnosed only at the time of cholecystectomy. The other 15 patients presented with laboratory and imaging findings consistent with choledocholithiasis and underwent preoperative endoscopic retrograde cholangiopancreatography, which established the diagnosis in all but one patient. All patients underwent cholecystectomy. An initial laparoscopic approach was attempted in 14 patients, of whom 11 were converted to open procedures. MS was recognized operatively in 15 patients with definitive stone extraction and relief of obstruction in 13 patients. T-tubes were placed in 10 patients and 1 patient required a choledochoduodenostomy. Two patients required postoperative laser lithotripsy via a T-tube tract to clear their stones; and in another patient, MS was detected and treated via postoperative endoscopic retrograde cholangiopancreatography (ERCP). MS remains a serious diagnostic and therapeutic challenge for endoscopists and biliary surgeons.

Original languageEnglish (US)
Pages (from-to)1022-1028
Number of pages7
JournalJournal of Gastrointestinal Surgery
Issue number6
StatePublished - Jun 2008


  • Cholangiopancreatography
  • Cholecystectomy
  • Choledocholithiasis
  • Cholelithiasis
  • Endoscopic retrograde
  • Mirizzi syndrome

ASJC Scopus subject areas

  • Gastroenterology
  • Surgery


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