The medullary thick limb: Function and modulation of the single-effect multiplier

S. C. Hebert, W. B. Reeves, D. A. Molony, T. E. Andreoli

Research output: Contribution to journalReview articlepeer-review

54 Scopus citations


This article will focus particularly on the transport functions of the medullary segment. The specific issues discussed will include the mechanism of NaCl absorption by the mTALH, the enhancement of this salt absorptive process by antiduiretic hormone (ADH), at least in certain mammalian species, and the major factors that appear to regulate or modulate both ADH-dependent and -independent NaCl transport processes. Sufficient information is currently available which indicates that these modulating factors provide feedback loops which sense interstitial osmolality and serve as a means of controlling the magnitude of interstitial hypertonicity, and hence concentrating power.

Original languageEnglish (US)
Pages (from-to)580-589
Number of pages10
JournalKidney international
Issue number2
StatePublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • Nephrology


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