The marmoset as a model of aging and age-related diseases

Suzette D. Tardif, Keith G. Mansfield, Rama Ratnam, Corinna N. Ross, Toni E. Ziegler

Research output: Contribution to journalArticle

123 Scopus citations

Abstract

The common marmoset (Callithrix jacchus) is poised to become a standard nonhuman primate aging model. With an average lifespan of 5 to 7 years and a maximum lifespan of 161/2 years, marmosets are the shortest-lived anthropoid primates. They display age-related changes in pathologies that mirror those seen in humans, such as cancer, amyloidosis, diabetes, and chronic renal disease. They also display predictable age-related differences in lean mass, calf circumference, circulating albumin, hemoglobin, and hematocrit. Features of spontaneous sensory and neurodegenerative change-for example, reduced neurogenesis, β-amyloid deposition in the cerebral cortex, loss of calbindin D28k binding, and evidence of presbycusis-appear between the ages of 7 and 10 years. Variation among colonies in the age at which neurodegenerative change occurs suggests the interesting possibility that marmosets could be specifi cally managed to produce earlier versus later occurrence of degenerative conditions associated with differing rates of damage accumulation. In addition to the established value of the marmoset as a model of age-related neurodegenerative change, this primate can serve as a model of the integrated effects of aging and obesity on metabolic dysfunction, as it displays evidence of such dysfunction associated with high body weight as early as 6 to 8 years of age.

Original languageEnglish (US)
Pages (from-to)54-65
Number of pages12
JournalILAR Journal
Volume52
Issue number1
DOIs
StatePublished - 2011

Keywords

  • Aging research
  • Hearing loss
  • Marmoset (callithrix jacchus)
  • Neurodegeneration
  • Nonhuman primate (NHP)
  • Obesity

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Biochemistry, Genetics and Molecular Biology(all)

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    Tardif, S. D., Mansfield, K. G., Ratnam, R., Ross, C. N., & Ziegler, T. E. (2011). The marmoset as a model of aging and age-related diseases. ILAR Journal, 52(1), 54-65. https://doi.org/10.1093/ilar.52.1.54