The MAM rodent model of schizophrenia

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Rodent models of human disease are essential to obtain a better understanding of disease pathology, the mechanism of action underlying conventional treatments, as well as for the generation of novel therapeutic approaches. There are a number of rodent models of schizophrenia based on either genetic manipulations, acute or sub-chronic drug administration, or developmental disturbances. The prenatal methylazoxymethanol acetate (MAM) rodent model is a developmental disruption model gaining increased attention because it displays a number of histological, neurophysiological, and behavioral deficits analogous to those observed in schizophrenia patients. This unit describes the procedures required to safely induce the MAM phenotype in rats. In addition, we describe a simple behavioral procedure, amphetamine-induced hyperlocomotion, which can be utilized to verify the MAM phenotype.

Original languageEnglish (US)
Article number9.43
JournalCurrent Protocols in Neuroscience
Issue numberSUPPL.63
DOIs
StatePublished - 2013

Fingerprint

Methylazoxymethanol Acetate
Rodentia
Schizophrenia
Phenotype
Amphetamine
Pathology
Therapeutics
Pharmaceutical Preparations

Keywords

  • Amphetamine
  • Locomotor activity
  • Methylazoxymethanol acetate
  • Rodent model
  • Schizophrenia

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

Cite this

The MAM rodent model of schizophrenia. / Lodge, Daniel J.

In: Current Protocols in Neuroscience, No. SUPPL.63, 9.43, 2013.

Research output: Contribution to journalArticle

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