The machinery of local Ca2+ signalling between sarco-endoplasmic reticulum and mitochondria

György Hajnóczky, György Csordás, Muniswamy Madesh, Pál Pacher

Research output: Contribution to journalReview articlepeer-review

179 Scopus citations


Growing evidence suggests that propagation of cytosolic [Ca2+] ([Ca2+](c)) spikes and oscillations to the mitochondria is important for the control of fundamental cellular functions. Delivery of [Ca2+](c) spikes to the mitochondria may utilize activation of the mitochondrial Ca2+ uptake sites by the large local [Ca2+](c) rise occurring in the vicinity of activated sarco-endoplasmic reticulum (SR/ER) Ca2+ release channels. Although direct measurement of the local [Ca2+](c) sensed by the mitochondria has been difficult, recent studies shed some light onto the molecular mechanism of local Ca2+ communication between SR/ER and mitochondria. Subdomains of the SR/ER are in close contact with mitochondria and display a concentration of Ca2+ release sites, providing the conditions for an effective delivery of released Ca2+ to the mitochondrial targets. Furthermore, many functional properties of the signalling between SR/ER Ca2+ release sites and mitochondrial Ca2+ uptake sites, including transient microdomains of high [Ca2+], saturation of mitochondrial Ca2+ uptake sites by released Ca2+, connection of multiple release sites to each uptake site and quantal transmission, are analogous to the features of the coupling between neuro-transmitter release sites and postsynaptic receptors in synaptic transmission. As such, Ca2+ signal transmission between SR/ER and mitochondria may utilize discrete communication sites and a closely related functional architecture to that used for synaptic signal propagation between cells.

Original languageEnglish (US)
Pages (from-to)69-81
Number of pages13
JournalJournal of Physiology
Issue number1
StatePublished - Nov 15 2000
Externally publishedYes

ASJC Scopus subject areas

  • Physiology


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