Abstract
A zinc-finger gene encoding a transcription factor that regulates hematopoiesis, MZF-1, is located at the extreme end of the q arm of human chromosome 19. Several lines of evidence indicate that MZF-1 lies less than 20 kb from the subtelomeric repeat region of 19q. Telomeres are known to degenerate as cells age; disruption of MZF-1 due to telomeric degeneration may play a role in the increased incidence of leukemia in the elderly.
Original language | English (US) |
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Pages (from-to) | 281-283 |
Number of pages | 3 |
Journal | Leukemia Research |
Volume | 20 |
Issue number | 3 |
DOIs | |
State | Published - Mar 1996 |
Externally published | Yes |
Keywords
- Hematopoesis
- MZF-1
- Telomeric degeneration
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research