The location of MZF-1 at the telomere of human chromosome 19q makes it vulnerable to degeneration in aging cells

Susan M.G. Hoffman; Robert Hromas; Chris Amemiya; Harvey W. Mohrenweiser

doi:10.1016/0145-2126(95)00158-1

The location of MZF-1 at the telomere of human chromosome 19q makes it vulnerable to degeneration in aging cells

Susan M.G. Hoffman, Robert Hromas, Chris Amemiya, Harvey W. Mohrenweiser

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

A zinc-finger gene encoding a transcription factor that regulates hematopoiesis, MZF-1, is located at the extreme end of the q arm of human chromosome 19. Several lines of evidence indicate that MZF-1 lies less than 20 kb from the subtelomeric repeat region of 19q. Telomeres are known to degenerate as cells age; disruption of MZF-1 due to telomeric degeneration may play a role in the increased incidence of leukemia in the elderly.

Original language	English (US)
Pages (from-to)	281-283
Number of pages	3
Journal	Leukemia Research
Volume	20
Issue number	3
DOIs	https://doi.org/10.1016/0145-2126(95)00158-1
State	Published - Mar 1996
Externally published	Yes

Keywords

Hematopoesis
MZF-1
Telomeric degeneration

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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title = "The location of MZF-1 at the telomere of human chromosome 19q makes it vulnerable to degeneration in aging cells",

abstract = "A zinc-finger gene encoding a transcription factor that regulates hematopoiesis, MZF-1, is located at the extreme end of the q arm of human chromosome 19. Several lines of evidence indicate that MZF-1 lies less than 20 kb from the subtelomeric repeat region of 19q. Telomeres are known to degenerate as cells age; disruption of MZF-1 due to telomeric degeneration may play a role in the increased incidence of leukemia in the elderly.",

keywords = "Hematopoesis, MZF-1, Telomeric degeneration",

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year = "1996",

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language = "English (US)",

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AU - Hoffman, Susan M.G.

AU - Hromas, Robert

AU - Amemiya, Chris

AU - Mohrenweiser, Harvey W.

PY - 1996/3

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N2 - A zinc-finger gene encoding a transcription factor that regulates hematopoiesis, MZF-1, is located at the extreme end of the q arm of human chromosome 19. Several lines of evidence indicate that MZF-1 lies less than 20 kb from the subtelomeric repeat region of 19q. Telomeres are known to degenerate as cells age; disruption of MZF-1 due to telomeric degeneration may play a role in the increased incidence of leukemia in the elderly.

AB - A zinc-finger gene encoding a transcription factor that regulates hematopoiesis, MZF-1, is located at the extreme end of the q arm of human chromosome 19. Several lines of evidence indicate that MZF-1 lies less than 20 kb from the subtelomeric repeat region of 19q. Telomeres are known to degenerate as cells age; disruption of MZF-1 due to telomeric degeneration may play a role in the increased incidence of leukemia in the elderly.

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KW - MZF-1

KW - Telomeric degeneration

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