Abstract
A zinc-finger gene encoding a transcription factor that regulates hematopoiesis, MZF-1, is located at the extreme end of the q arm of human chromosome 19. Several lines of evidence indicate that MZF-1 lies less than 20 kb from the subtelomeric repeat region of 19q. Telomeres are known to degenerate as cells age; disruption of MZF-1 due to telomeric degeneration may play a role in the increased incidence of leukemia in the elderly.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 281-283 |
| Number of pages | 3 |
| Journal | Leukemia Research |
| Volume | 20 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 1 1996 |
| Externally published | Yes |
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Keywords
- Hematopoesis
- MZF-1
- Telomeric degeneration
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research
Cite this
The location of MZF-1 at the telomere of human chromosome 19q makes it vulnerable to degeneration in aging cells. / Hoffman, Susan M.G.; Hromas, Robert A; Amemiya, Chris; Mohrenweiser, Harvey W.
In: Leukemia Research, Vol. 20, No. 3, 01.01.1996, p. 281-283.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The location of MZF-1 at the telomere of human chromosome 19q makes it vulnerable to degeneration in aging cells
AU - Hoffman, Susan M.G.
AU - Hromas, Robert A
AU - Amemiya, Chris
AU - Mohrenweiser, Harvey W.
PY - 1996/1/1
Y1 - 1996/1/1
N2 - A zinc-finger gene encoding a transcription factor that regulates hematopoiesis, MZF-1, is located at the extreme end of the q arm of human chromosome 19. Several lines of evidence indicate that MZF-1 lies less than 20 kb from the subtelomeric repeat region of 19q. Telomeres are known to degenerate as cells age; disruption of MZF-1 due to telomeric degeneration may play a role in the increased incidence of leukemia in the elderly.
AB - A zinc-finger gene encoding a transcription factor that regulates hematopoiesis, MZF-1, is located at the extreme end of the q arm of human chromosome 19. Several lines of evidence indicate that MZF-1 lies less than 20 kb from the subtelomeric repeat region of 19q. Telomeres are known to degenerate as cells age; disruption of MZF-1 due to telomeric degeneration may play a role in the increased incidence of leukemia in the elderly.
KW - Hematopoesis
KW - MZF-1
KW - Telomeric degeneration
UR - http://www.scopus.com/inward/record.url?scp=0029863179&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029863179&partnerID=8YFLogxK
U2 - 10.1016/0145-2126(95)00158-1
DO - 10.1016/0145-2126(95)00158-1
M3 - Article
C2 - 8637224
AN - SCOPUS:0029863179
VL - 20
SP - 281
EP - 283
JO - Leukemia Research
JF - Leukemia Research
SN - 0145-2126
IS - 3
ER -