The location of MZF-1 at the telomere of human chromosome 19q makes it vulnerable to degeneration in aging cells

Susan M.G. Hoffman, Robert Hromas, Chris Amemiya, Harvey W. Mohrenweiser

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

A zinc-finger gene encoding a transcription factor that regulates hematopoiesis, MZF-1, is located at the extreme end of the q arm of human chromosome 19. Several lines of evidence indicate that MZF-1 lies less than 20 kb from the subtelomeric repeat region of 19q. Telomeres are known to degenerate as cells age; disruption of MZF-1 due to telomeric degeneration may play a role in the increased incidence of leukemia in the elderly.

Original languageEnglish (US)
Pages (from-to)281-283
Number of pages3
JournalLeukemia Research
Volume20
Issue number3
DOIs
StatePublished - Mar 1996
Externally publishedYes

Keywords

  • Hematopoesis
  • MZF-1
  • Telomeric degeneration

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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