The location of MZF-1 at the telomere of human chromosome 19q makes it vulnerable to degeneration in aging cells

Susan M.G. Hoffman, Robert A Hromas, Chris Amemiya, Harvey W. Mohrenweiser

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A zinc-finger gene encoding a transcription factor that regulates hematopoiesis, MZF-1, is located at the extreme end of the q arm of human chromosome 19. Several lines of evidence indicate that MZF-1 lies less than 20 kb from the subtelomeric repeat region of 19q. Telomeres are known to degenerate as cells age; disruption of MZF-1 due to telomeric degeneration may play a role in the increased incidence of leukemia in the elderly.

Original languageEnglish (US)
Pages (from-to)281-283
Number of pages3
JournalLeukemia Research
Volume20
Issue number3
DOIs
StatePublished - Jan 1 1996
Externally publishedYes

Fingerprint

Chromosomes, Human, Pair 19
Cell Aging
Zinc Fingers
Telomere
Hematopoiesis
Human Chromosomes
Leukemia
Transcription Factors
Incidence
Genes

Keywords

  • Hematopoesis
  • MZF-1
  • Telomeric degeneration

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

The location of MZF-1 at the telomere of human chromosome 19q makes it vulnerable to degeneration in aging cells. / Hoffman, Susan M.G.; Hromas, Robert A; Amemiya, Chris; Mohrenweiser, Harvey W.

In: Leukemia Research, Vol. 20, No. 3, 01.01.1996, p. 281-283.

Research output: Contribution to journalArticle

Hoffman, Susan M.G. ; Hromas, Robert A ; Amemiya, Chris ; Mohrenweiser, Harvey W. / The location of MZF-1 at the telomere of human chromosome 19q makes it vulnerable to degeneration in aging cells. In: Leukemia Research. 1996 ; Vol. 20, No. 3. pp. 281-283.
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