The location of MZF-1 at the telomere of human chromosome 19q makes it vulnerable to degeneration in aging cells

Susan M.G. Hoffman; Robert Hromas; Chris Amemiya; Harvey W. Mohrenweiser

doi:10.1016/0145-2126(95)00158-1

The location of MZF-1 at the telomere of human chromosome 19q makes it vulnerable to degeneration in aging cells

Susan M.G. Hoffman, Robert Hromas, Chris Amemiya, Harvey W. Mohrenweiser

Research output: Contribution to journal › Article

12 Scopus citations

Abstract

A zinc-finger gene encoding a transcription factor that regulates hematopoiesis, MZF-1, is located at the extreme end of the q arm of human chromosome 19. Several lines of evidence indicate that MZF-1 lies less than 20 kb from the subtelomeric repeat region of 19q. Telomeres are known to degenerate as cells age; disruption of MZF-1 due to telomeric degeneration may play a role in the increased incidence of leukemia in the elderly.

Original language	English (US)
Pages (from-to)	281-283
Number of pages	3
Journal	Leukemia Research
Volume	20
Issue number	3
DOIs	https://doi.org/10.1016/0145-2126(95)00158-1
State	Published - Mar 1996
Externally published	Yes

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Keywords

Hematopoesis
MZF-1
Telomeric degeneration

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

Cite this

Hoffman, S. M. G., Hromas, R., Amemiya, C., & Mohrenweiser, H. W. (1996). The location of MZF-1 at the telomere of human chromosome 19q makes it vulnerable to degeneration in aging cells. Leukemia Research, 20(3), 281-283. https://doi.org/10.1016/0145-2126(95)00158-1

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Access to Document

10.1016/0145-2126(95)00158-1