The lack of initiating and/or promoting activity of sodium malondialdehyde on SENCAR mouse skin

Susan M. Fischer; Shirley Ogle; Lawrence J. Marnett; Stephen Nesnow; Thomas J. Slaga

doi:10.1016/0304-3835(83)90136-2

The lack of initiating and/or promoting activity of sodium malondialdehyde on SENCAR mouse skin

Susan M. Fischer, Shirley Ogle, Lawrence J. Marnett, Stephen Nesnow, Thomas J. Slaga

Research output: Contribution to journal › Article

20 Scopus citations

Abstract

Malondialdehyde (MDA), a lipid peroxidation product, has been implicated in carcinogenesis, in part for its reported mutagenic activity. It was of interest therefore, to determine its activity as either a complete carcinogen, a tumor initiator, or a tumor promoter. Using the SENCAR mouse skin model, pure sodium MDA (NaMDA) was found to lack activity in any of these categories. Furthermore, NaMDA was determined to be negative in the Chinese hamster V-79 metabolic cooperation assay for promoters.

Original language	English (US)
Pages (from-to)	61-66
Number of pages	6
Journal	Cancer Letters
Volume	19
Issue number	1
DOIs	https://doi.org/10.1016/0304-3835(83)90136-2
State	Published - May 1983
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

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Fischer, S. M., Ogle, S., Marnett, L. J., Nesnow, S., & Slaga, T. J. (1983). The lack of initiating and/or promoting activity of sodium malondialdehyde on SENCAR mouse skin. Cancer Letters, 19(1), 61-66. https://doi.org/10.1016/0304-3835(83)90136-2

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