TY - JOUR
T1 - The lack of initiating and/or promoting activity of sodium malondialdehyde on SENCAR mouse skin
AU - Fischer, Susan M.
AU - Ogle, Shirley
AU - Marnett, Lawrence J.
AU - Nesnow, Stephen
AU - Slaga, Thomas J.
PY - 1983/5
Y1 - 1983/5
N2 - Malondialdehyde (MDA), a lipid peroxidation product, has been implicated in carcinogenesis, in part for its reported mutagenic activity. It was of interest therefore, to determine its activity as either a complete carcinogen, a tumor initiator, or a tumor promoter. Using the SENCAR mouse skin model, pure sodium MDA (NaMDA) was found to lack activity in any of these categories. Furthermore, NaMDA was determined to be negative in the Chinese hamster V-79 metabolic cooperation assay for promoters.
AB - Malondialdehyde (MDA), a lipid peroxidation product, has been implicated in carcinogenesis, in part for its reported mutagenic activity. It was of interest therefore, to determine its activity as either a complete carcinogen, a tumor initiator, or a tumor promoter. Using the SENCAR mouse skin model, pure sodium MDA (NaMDA) was found to lack activity in any of these categories. Furthermore, NaMDA was determined to be negative in the Chinese hamster V-79 metabolic cooperation assay for promoters.
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U2 - 10.1016/0304-3835(83)90136-2
DO - 10.1016/0304-3835(83)90136-2
M3 - Article
C2 - 6850569
AN - SCOPUS:0020954899
VL - 19
SP - 61
EP - 66
JO - Cancer Letters
JF - Cancer Letters
SN - 0304-3835
IS - 1
ER -