The lack of initiating and/or promoting activity of sodium malondialdehyde on SENCAR mouse skin

Susan M. Fischer, Shirley Ogle, Lawrence J. Marnett, Stephen Nesnow, Thomas J. Slaga

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Malondialdehyde (MDA), a lipid peroxidation product, has been implicated in carcinogenesis, in part for its reported mutagenic activity. It was of interest therefore, to determine its activity as either a complete carcinogen, a tumor initiator, or a tumor promoter. Using the SENCAR mouse skin model, pure sodium MDA (NaMDA) was found to lack activity in any of these categories. Furthermore, NaMDA was determined to be negative in the Chinese hamster V-79 metabolic cooperation assay for promoters.

Original languageEnglish (US)
Pages (from-to)61-66
Number of pages6
JournalCancer Letters
Volume19
Issue number1
DOIs
StatePublished - May 1983
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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