TY - JOUR
T1 - The Kidney
T2 - An Organ in the Front Line of Oxidative Stress-Associated Pathologies
AU - Gorin, Yves
N1 - Funding Information:
Y.G. is funded by the National Institutes of Health (NIH) Grants UL1 TR001120, RO1 DK 079996, and RO1 DK 33665 as well as an award from the Qatar National Research Fund, National Priorities Research Program (NPRP8-1750-3-360).
Publisher Copyright:
© Copyright 2016, Mary Ann Liebert, Inc.
PY - 2016/10/20
Y1 - 2016/10/20
N2 - Both acute kidney injury (AKI) and chronic kidney disease (CKD) are major causes of renal failure in humans and are associated with high incidences of morbidity and mortality rates. AKI and CKD are closely interconnected, and fueled by the obesity and diabetes epidemic, their prevalence is alarmingly increasing to the point that it currently represents a major heath issue worldwide. The kidney is an organ that is particularly sensitive to redox imbalance, resulting in excessive production of reactive oxygen species. Oxidative stress is viewed as a critical pathogenic factor implicated in the initiation, development, and progression of most renal diseases. This Forum discusses the redox-dependent factors and mechanisms accounting for the perturbation of renal function and circulation in the context of the major kidney pathologies linked to hypertension, diabetes, and cancer. Antioxid. Redox Signal. 25, 639-641.
AB - Both acute kidney injury (AKI) and chronic kidney disease (CKD) are major causes of renal failure in humans and are associated with high incidences of morbidity and mortality rates. AKI and CKD are closely interconnected, and fueled by the obesity and diabetes epidemic, their prevalence is alarmingly increasing to the point that it currently represents a major heath issue worldwide. The kidney is an organ that is particularly sensitive to redox imbalance, resulting in excessive production of reactive oxygen species. Oxidative stress is viewed as a critical pathogenic factor implicated in the initiation, development, and progression of most renal diseases. This Forum discusses the redox-dependent factors and mechanisms accounting for the perturbation of renal function and circulation in the context of the major kidney pathologies linked to hypertension, diabetes, and cancer. Antioxid. Redox Signal. 25, 639-641.
KW - oxidative stress
KW - reactive oxygen species
KW - renal injury
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U2 - 10.1089/ars.2016.6804
DO - 10.1089/ars.2016.6804
M3 - Review article
C2 - 27357313
AN - SCOPUS:84991738516
VL - 25
SP - 639
EP - 641
JO - Antioxidants and Redox Signaling
JF - Antioxidants and Redox Signaling
SN - 1523-0864
IS - 12
ER -