The Kidney: An Organ in the Front Line of Oxidative Stress-Associated Pathologies

Yves Gorin

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations

Abstract

Both acute kidney injury (AKI) and chronic kidney disease (CKD) are major causes of renal failure in humans and are associated with high incidences of morbidity and mortality rates. AKI and CKD are closely interconnected, and fueled by the obesity and diabetes epidemic, their prevalence is alarmingly increasing to the point that it currently represents a major heath issue worldwide. The kidney is an organ that is particularly sensitive to redox imbalance, resulting in excessive production of reactive oxygen species. Oxidative stress is viewed as a critical pathogenic factor implicated in the initiation, development, and progression of most renal diseases. This Forum discusses the redox-dependent factors and mechanisms accounting for the perturbation of renal function and circulation in the context of the major kidney pathologies linked to hypertension, diabetes, and cancer. Antioxid. Redox Signal. 25, 639-641.

Original languageEnglish (US)
Pages (from-to)639-641
Number of pages3
JournalAntioxidants and Redox Signaling
Volume25
Issue number12
DOIs
StatePublished - Oct 20 2016

Keywords

  • oxidative stress
  • reactive oxygen species
  • renal injury

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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