The key role of the sequential proton loss electron transfer mechanism on the free radical scavenging activity of some melatonin-related compounds

Ruslán Álvarez-Diduk, Annia Galano, Dun Xian Tan, Russel J Reiter

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The role of the acid–base equilibria and the sequential proton loss electron transfer mechanism (SPLET) on the free radical scavenging activity of six melatonin-related compounds was investigated using the density functional theory. It was found that this chemical route is particularly important for about half of the studied compounds. Some of their pKa values are reported here for the first time. In addition, our results also indicate that anionic species, presenting the phenolate moiety, may be crucial to scavenge peroxyl radicals albeit their populations are relatively low at physiological pH. The key number to consider in this context should be the product of the molar fraction of the reacting compound, at the pH of interest, by the corresponding rate constant.

Original languageEnglish (US)
Article number38
Pages (from-to)1-5
Number of pages5
JournalTheoretical Chemistry Accounts
Volume135
Issue number2
DOIs
StatePublished - Feb 1 2016

Fingerprint

melatonin
Scavenging
scavenging
Melatonin
free radicals
Free Radicals
Density functional theory
Protons
Rate constants
electron transfer
protons
Electrons
routes
density functional theory
products
perhydroxyl radical

Keywords

  • Antioxidant activity
  • DFT
  • Kinetics
  • pKa
  • Reaction mechanisms
  • SPLET

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry

Cite this

The key role of the sequential proton loss electron transfer mechanism on the free radical scavenging activity of some melatonin-related compounds. / Álvarez-Diduk, Ruslán; Galano, Annia; Tan, Dun Xian; Reiter, Russel J.

In: Theoretical Chemistry Accounts, Vol. 135, No. 2, 38, 01.02.2016, p. 1-5.

Research output: Contribution to journalArticle

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