TY - JOUR
T1 - The journey from NADPH-cytochrome P450 oxidoreductase to nitric oxide synthases
AU - Masters, Bettie Sue Siler
N1 - Funding Information:
Supported by National Institutes of Health Grant Nos. HL30050, GM52419, and GM31296 and Robert A. Welch Foundation Grant No. AQ-1192 to B.S.S.M.
PY - 2005/12/9
Y1 - 2005/12/9
N2 - This mini-review will reflect the perspective of its author on two fields of research, which have merged as the result of the insights of investigators whose work has influenced both areas immeasurably. It cannot be overlooked, however, that the research activities of many during a period of over five decades have produced the chemical and biological bases for the exciting discoveries now encompassing the cytochromes P450 and their redox partners, and the three isoforms of nitric oxide synthase as they function in their respective biological milieux. Following the remarkable discovery that, indeed, molecular oxygen can be adducted to organic molecules by enzymatic systems and that such processes require a supply of reducing equivalents, it is the purpose of this review to provide a chart, with some of its detours, of the road that followed in the pursuit of interesting biological phenomena involving these two major oxygenation systems. It is not intended to be a balanced review and apologies must be offered in advance to those whose contributions may be overlooked or simply were not directly germane to the development of the author's journey.
AB - This mini-review will reflect the perspective of its author on two fields of research, which have merged as the result of the insights of investigators whose work has influenced both areas immeasurably. It cannot be overlooked, however, that the research activities of many during a period of over five decades have produced the chemical and biological bases for the exciting discoveries now encompassing the cytochromes P450 and their redox partners, and the three isoforms of nitric oxide synthase as they function in their respective biological milieux. Following the remarkable discovery that, indeed, molecular oxygen can be adducted to organic molecules by enzymatic systems and that such processes require a supply of reducing equivalents, it is the purpose of this review to provide a chart, with some of its detours, of the road that followed in the pursuit of interesting biological phenomena involving these two major oxygenation systems. It is not intended to be a balanced review and apologies must be offered in advance to those whose contributions may be overlooked or simply were not directly germane to the development of the author's journey.
UR - http://www.scopus.com/inward/record.url?scp=27544462706&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=27544462706&partnerID=8YFLogxK
U2 - 10.1016/j.bbrc.2005.09.165
DO - 10.1016/j.bbrc.2005.09.165
M3 - Review article
C2 - 16246311
AN - SCOPUS:27544462706
VL - 338
SP - 507
EP - 519
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 1
ER -